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FAM3B Rabbit pAb (bs-0711R)  
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產品編號 bs-0711R
英文名稱 FAM3B Rabbit pAb
中文名稱 胰腺衍生因子抗體
別    名 C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.  
研究領域 免疫學  細胞凋亡  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 23 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAM3B: 1-100/235 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.

Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Subcellular Location:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Tissue Specificity:
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Post-translational modifications:
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.

Similarity:
Belongs to the FAM3 family.

SWISS:
P58499

Gene ID:
54097

Database links:

Entrez Gene: 54097 Human

Entrez Gene: 52793 Mouse

Omim: 608617 Human

SwissProt: P58499 Human

SwissProt: Q9D309 Mouse

Unigene: 473877 Human

Unigene: 670704 Human

Unigene: 327932 Mouse



胰腺衍生因子(PANcreatic DERived fa*ctor,PANDER)是新發現的一種新型的胰島細胞因子、由胰島α細胞和β細胞分泌的一種分泌型細胞因子,與β細胞凋亡密切相關 ,可以誘導胰島素分泌β細胞,主要用于糖尿病的研究。
產品圖片
Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated(bs-0711R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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