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FGL2 Rabbit pAb (bs-0315R)  
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產品編號 bs-0315R
英文名稱 FGL2 Rabbit pAb
中文名稱 凝血酶原酶/纖維蛋白原2抗體
別    名 Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN.  
Specific References  (1)     |     bs-0315R has been referenced in 1 publications.
[IF=34.661] Yang, Siyoung, et al. "Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance." Science 348.6234 (2015): 589-594.  FCM ;  Mouse.  
研究領域 免疫學  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 49 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Rat FGL2: 75-150/422 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1.

Function:
May play a role in physiologic lymphocyte functions at mucosal sites

Subunit:
Homotetramer; disulfide-linked.

Subcellular Location:
Secreted.

Tissue Specificity:
Constitutively expressed in cytotoxic T-cells.

Similarity:
Contains 1 fibrinogen C-terminal domain.

Gene ID:
84586

Database links:

Entrez Gene: 511711 Cow

Entrez Gene: 10875 Human

Entrez Gene: 14190 Mouse

Entrez Gene: 84586 Rat

Omim: 605351 Human

SwissProt: Q14314 Human

SwissProt: P12804 Mouse

Unigene: 520989 Human

Unigene: 292100 Mouse



fgL-2蛋白是新近發現的一種凝血因子,它通過直接激活凝血酶原啟動凝血過程。一 系列實驗證明,該蛋白在肝細胞壞死中起到重要作用。對乙肝患者肝組織免疫組織化學染色hfg12在重型乙型肝炎患者高表達。
凝血酶原酶(簡稱fgl2)蛋白屬于纖維蛋白原家族的一員,由活化的巨噬細胞表達,具有凝血酶原酶的活力,能催化凝血酶原轉化為凝血酶,啟動凝血過程.
產品圖片
Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-fg-12 Polyclonal Antibody, Unconjugated(bs-0315R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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