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TNFRSF18 Rabbit pAb (bs-1173R)  
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產品編號 bs-1173R
英文名稱 TNFRSF18 Rabbit pAb
中文名稱 糖皮質激素誘導腫瘤壞死因子受體抗體
別    名 Activation inducible TNFR family receptor; Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR D; GITR-D; GITRD; Glucocorticoid induced TNFR related protein; glucocorticoid-induced tnf receptor ligand; glucocorticoid-induced tnf receptors ligand; Glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation inducible protein; TNFRSF 18; TNR18_HUMAN; Tumor necrosis factor receptor superfamily member 18; Tumor necrosis factor receptor superfamily member 18 precursor;  
研究領域 腫瘤  細胞生物  免疫學  生長因子和激素  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse TNFRSF18: 201-214/228 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

Function:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Subunit:
Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Tissue Specificity:
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Similarity:
Contains 3 TNFR-Cys repeats.

SWISS:
O35714

Gene ID:
21936

Database links:

Entrez Gene: 8784 Human

Entrez Gene: 21936 Mouse

Omim: 603905 Human

SwissProt: Q9Y5U5 Human

SwissProt: O35714 Mouse

Unigene: 212680 Human

Unigene: 3180 Mouse

Unigene: 482508 Mouse



GITR屬于腫瘤壞死因子受體超家族(TNFRSF),GITR參與免疫調節信號,在T細胞的活化、凋亡,尤其是阻斷調節性T細胞(T regulatory cell)的抑制功能等活動中發揮主要作用。
產品圖片
Tissue/cell: human oral squamous cell carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩?? for 20 min; Incubation: Anti-TNFRSF18 Polyclonal Antibody, Unconjugated(bs-1173R) 1:200, overnight at 4擄C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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