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P311 Rabbit pAb (bs-0427R)  
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50ul/1180.00元
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產品編號 bs-0427R
英文名稱 P311 Rabbit pAb
中文名稱 神經再生相關蛋白抗體
別    名 NREP; Neuronal regeneration-related protein; C5orf13; Neuronal protein 3.1; PRO1873; Protein p311; P311 protein; Chromosome 5 open reading frame 13; D4S114; PTZ17; NREP_HUMAN.  
Specific References  (7)     |     bs-0427R has been referenced in 7 publications.
[IF=12.121] Cheng-Cheng Deng. et al. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun. 2021 Jun;12(1):1-16  IF ;  Human.  
[IF=5.23] Yao, Zhihui, et al. "P311 promotes renal fibrosis via TGFβ1/Smad signaling." Scientific reports 5 (2015).  IHC-P ;  Mouse.  
[IF=4.966] Du Y et al. Butyrate alleviates diabetic kidney disease by mediating the miR‐7a‐5p/P311/TGF‐β1 pathway. FASEB J . 2020 Aug;34(8):10462-10475.  WB&IHC-P ;  Mouse.  
[IF=4.5] Li, Haisheng, et al. "P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression." Stem Cell Research & Therapy 7.1 (2016): 175.  IHC-P ;  Human.  
[IF=4.5] Yao, Zhihui, et al. "P311 accelerates skin wound reepithelialization by promoting epidermal stem cell migration through Rho A and Rac1 activation." Stem Cells and Development ja (2016).  IHC-P ;  Human, Mouse.  
[IF=1.44] Zhang et al. Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells. (2015) Ren.Fail. 37:1384-9  ICC ;  Rat.  
[IF=0.16] Peng, Xu, et al. "Identification of ITGB4BP as a new interaction protein of P311." Life Sciences (2012).  Human.  
研究領域 腫瘤  心血管  細胞生物  神經生物學  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 7.9 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human P311: 25-68/68 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 P311, also called PTZ17, was identified by suppressive subtraction hybridization as potentially involved in smooth muscle (SM) myogenesis., an 8-kDa polypeptide, was previously shown to be highly expressed in invasive glioma cells. P311 is constitutively serine-phosphorylated; decreased phosphorylation is observed in migration-activated glioma cells. The primary amino acid sequence of P311 indicates a putative serine phosphorylation site (S59) near the PEST domain. Site-directed mutagenesis of S59A retarded P311 degradation and induced glioma cell motility. In contrast, S59D mutation resulted in the rapid degradation of P311 and reduced glioma cell migration.

Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Subunit:
Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in lung (at protein level).

Post-translational modifications:
Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

SWISS:
Q16612

Gene ID:
9315

Database links:

Entrez Gene: 9315 Human

Entrez Gene: 27528 Mouse

Entrez Gene: 338475 Rat

Omim: 607332 Human

SwissProt: Q16612 Human

SwissProt: Q07475 Mouse

SwissProt: Q80Z34 Rat

Unigene: 36053 Human

Unigene: 694860 Human

Unigene: 728773 Human

Unigene: 407415 Mouse

Unigene: 8180 Rat



P311 protein 還稱:PTZ17 (pentylenetetrazd117)又稱:增生性瘢痕相關蛋白。該蛋白與燒傷后瘢痕增生修復有關。
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