97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕日韩在线观看,亚洲免费视,夜夜爽77777妓女免费看
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
TRF1 Rabbit pAb (bs-1151R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號 bs-1151R
英文名稱 TRF1 Rabbit pAb
中文名稱 端粒體復(fù)制結(jié)合因子1抗體
別    名 hTRF1 AS; NIMA interacting protein 2; NIMA-interacting protein 2; PIN 2; PIN2; t TRF1; Telomeric protein Pin2; Telomeric protein Pin2/TRF1; Telomeric repeat binding factor(NIMA interacting) 1; Telomeric repeat binding factor 1; Telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF 1; TERF1; TERF1_HUMAN; TRBF 1; TRBF1; TRF 1; TRF; TTAGGG repeat binding factor 1; TTAGGG repeat-binding factor 1.  
Specific References  (7)     |     bs-1151R has been referenced in 7 publications.
[IF=8.755] Chunfeng Lu. et al. ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized?PINK1/Parkin-mediated mitophagy. CELL PROLIFERAT. 2022 Dec;:e13378  WB ;  Human.  
[IF=6.831] Xiaoyu Qi. et al. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. 2021 Aug 03  WB ;  Hamsters.  
[IF=6.691] Jiang, Yiming. et al. Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. 2021 Aug 17  IF ;  Mouse.  
[IF=5.988] Qi Xiaoyu. et al. Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease. FRONT PHARMACOL. 2022 Jun;0:2140  WB ;  Human, Mouse.  
[IF=3.376] Esra Gozde Kosebent et al. The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse. Exp Gerontol. 2020 Sep;138:110975.  IHC ;  Mouse.  
[IF=2.829] Fatma Uysal. et al. Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. J Assist Reprod Gen. 2021 Feb;38(2):429-441  IHC ;  Human.  
[IF=1.951] Esra G. Kosebent. et al. The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes. 2021 Feb 05  IHC ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRBF1: 121-220/439 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq].

Function:
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Subunit:
Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation. Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interactions with GNL3L and TIN2 are mutually exclusive (By similarity).

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.

Tissue Specificity:
Highly expressed and ubiquitous. Isoform Pin2 predominates.

Post-translational modifications:
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.

Similarity:
Contains 1 HTH myb-type DNA-binding domain.

SWISS:
P54274

Gene ID:
7013

Database links:

Entrez Gene: 7013 Human

Entrez Gene: 21749 Mouse

Omim: 600951 Human

SwissProt: P54274 Human

SwissProt: P70371 Mouse

Unigene: 442707 Human

Unigene: 4306 Mouse



TRBF1端粒體復(fù)制結(jié)合因子1,在細(xì)胞周期的過程中都有該蛋白的存在,可抑制端粒酶的活性,限制染色體頂端的延長。端粒體復(fù)制結(jié)合因子1位于端粒體頂端,是端粒體核酸蛋白復(fù)合物的組成部分。
產(chǎn)品圖片
Sample: K562(Human) Cell Lysate at 30 ug Primary: Anti-TRF1 (bs-1151R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 49 kD
Sample: HL-60(Human) Cell Lysate at 30 ug Primary: Anti-TRF1 (bs-1151R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 49 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRF1) Polyclonal Antibody, Unconjugated (bs-1151R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 一区二区免费在线观看视频 | 亚洲成AV人片一区二区密柚 | 成人麻豆日韩在无码视频 | 亚洲第一黄色网址 | anquye在线观看| 一区二区三区精品视频免费看 | 久久不射2019中文字幕 | 久久99热狠狠色一区二区 | 高清国产午夜精品久久久久久 | 怡红院亚洲第一综合久久 | 成人在色线视频在线观看免费大全 | 网站黄色在线观看 | 蜜桃麻豆WWW久久囤产精品 | 天天爱天天做天天添天天欢 | 九九热精品6 | 亚洲自拍偷拍欧美 | ts在线观看| 国产实拍会所女技师在线观看 | 在线精品亚洲一区二区动态图 | 涩涩一区二区 | 午夜影视在线 | 免费精品99久久国产综合精品 | www日韩com| 一级特黄毛片 | 亚洲女同成av人片在线观看 | 国产成人福利视频 | av在线免费播放不卡 | 欧美一级久久久猛烈a大片 国产吹潮视频在线观看 | 清纯女学生强制中出在线观看 | 日韩资源在线观看 | 亚洲av爆乳精品一区二区中文 | 国产高清在线视频观看 | 影音先锋男人站 | 久久精品久久精品久久精品 | 亚洲欧美不卡 | 精品在线观看一区二区 | www.av视频在线观看 | av影视网 | 年轻母亲4在线 | 亚洲乱码久久久 | 久草免费在线视频观看 |