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CCR6 Rabbit pAb (bs-1542R)  
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產品編號 bs-1542R
英文名稱 CCR6 Rabbit pAb
中文名稱 細胞表面趨化因子受體6(CD196)抗體
別    名 CKR6; C-C chemokine receptor type 6; BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; CC chemokine receptor type 6; CC CKR 6; CC R6; CCCKR6; CCR 6; CD 196; CD196; CD196 antigen; Chemokine(C C motif) receptor 6; Chemokine(C C) receptor 6; Chemokine(CC motif) receptor 6; Chemokine(CC) receptor 6; Chemokine receptor 6; Chemokine receptor like 3; CKR 6; CKR L3; CKRL3; CMKBR 6; CMKBR6; DCR 2; DCR2; DRY 6; DRY6; G protein coupled receptor 29; GPR 29; GPR CY4; GPR29; GPRCY 4; GPRCY4; LARC receptor; Seven transmembrane receptor lymphocyte 22; STRL 22; STRL22; CCR6_HUMAN.  
Specific References  (3)     |     bs-1542R has been referenced in 3 publications.
[IF=7.242] Anne-Lise Paris. et al. Sublingual protein delivery by a mucoadhesive patch made of natural polymers. Acta Biomater. 2021 Apr;:  IHC ;  Mouse.  
[IF=4.757] Shan Huang. et al. Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus. BIOMEDICINES. 2023 Mar;11(3):955  WB ;  Human.  
[IF=3.457] Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151.  IHC ;  Human.  
研究領域 腫瘤  信號轉導  轉錄調節因子  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCR6 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Function:
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P51684

Gene ID:
1235

Database links:

Entrez Gene: 1235 Human

Entrez Gene: 12458 Mouse

Entrez Gene: 308163 Rat

Omim: 601835 Human

SwissProt: P51684 Human

SwissProt: O54689 Mouse

Unigene: 46468 Human

Unigene: 8007 Mouse



CCR6/CD196也是是屬于G蛋白偶聯受體一家族成員,參與調節白細胞的遷移和活性作用,是細胞膜蛋白。
產品圖片
Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-CCR6 (bs-1542R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa
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