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PGC Rabbit pAb (bs-1551R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-1551R
英文名稱 PGC Rabbit pAb
中文名稱 胃蛋白酶原C抗體
別    名 PEPC_HUMAN; Gastricsin; EC:3.4.23.3; Pepsinogen C; PEPC; PGII; progastricsin;  
Specific References  (1)     |     bs-1551R has been referenced in 1 publications.
[IF=14.919] Higa, Tsunaki. et al. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nat Commun. 2022 Mar;13(1):1-17  IF ;  Mouse.  
研究領(lǐng)域 腫瘤  信號轉(zhuǎn)導(dǎo)  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse,Rat (predicted: Cow,Chicken)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PGC: 21-120/388 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Function:
Hydrolyzes a variety of proteins.

Subcellular Location:
Secreted.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
P20142

Gene ID:
5225

Database links:

Entrez Gene: 5225 Human

Entrez Gene: 24864 Rat

Omim: 169740 Human

SwissProt: P20142 Human

SwissProt: P04073 Rat

Unigene: 1867 Human

Unigene: 9735 Rat



胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病變易感性的關(guān)系。
產(chǎn)品圖片
Sample: Lane 1: Mouse Stomach tissue lysates Lane 2: Rat Stomach tissue lysates Primary: Anti-PGC (bs-1551R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 38 kDa
Tissue/cell: Human gastric cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PGII Polyclonal Antibody, Unconjugated(bs-1551R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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