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CALCRL Rabbit pAb (bs-1860R)  
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產品編號 bs-1860R
英文名稱 CALCRL Rabbit pAb
中文名稱 降鈣素基因相關肽1型受體抗體
別    名 CGRPR; CRLR; calcitonin receptor like precursor; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; CGRP type 1 receptor; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; Calcitonin Receptor Like Receptor; CGRP type 1 receptor; CALRL_HUMAN.  
Specific References  (13)     |     bs-1860R has been referenced in 13 publications.
[IF=13.567] Baranowsky, Anke. et al. Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment. Bone Res. 2022 Jan;10(1):1-15  IF ;  Mouse.  
[IF=6.6] Romina Mancinelli. et al. The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling. CELLS-BASEL. 2022 Jan;11(9):1591  IHC ;  Mouse.  
[IF=6.116] E.R. Moore. et al. CGRP and Shh Mediate the Dental Pulp Cell Response to Neuron Stimulation:. J DENT RES. 0;():  IHC ;  Mouse.  
[IF=5.736] Jessika Appelt. et al. The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing. Ebiomedicine. 2020 Sep;59:102970  IF,IHC ;  Mouse.  
[IF=5.62] Fátima Gimeno-Ferrer. et al. From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex. EXP NEUROL. 2022 Oct;356:114152  IF ;  Rat.  
[IF=4.996] Jana, Barbara. et al. Involvement of the calcitonin gene-related peptide system in the modulation of inflamed uterus contractile function in pigs. SCI REP-UK. 2022 Nov;12(1):1-14  WB ;  Pig.  
[IF=4.6] Toriyama, Yuichi, et al. "Pathophysiological Function of Endogenous Calcitonin Gene–Related Peptide in Ocular Vascular Diseases." The American Journal of Pathology (2015).  Mouse.  
[IF=4.36] Muschter D et al. Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model. Bone.?2020 Jan 8;133:115181.  IHC-P ;  Mouse.  
[IF=4.225] Hou K et al. Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Na?ve Rats and Rats With Inflammatory Pain. Front Pharmacol. 2020 Jun 26;11:928.  WB ;  Rat.  
[IF=3.616] Shengcai Gu. et al. Interfering with CALCRL expression inhibits glioma proliferation, promotes apoptosis, and predicts prognosis in low-grade gliomas. ANN TRANSL MED. 2022 Dec;10(23):1277  IHC ;  Human.  
[IF=3.352] Laixi Luo. et al. Calcitonin gene-related peptide and its receptor plays important role in nociceptive regulation in the arcuate nucleus of hypothalamus of rats with inflammatory pain. BEHAV BRAIN RES. 2023 Feb;:114351  WB ;  Rat.  
[IF=3.347] Lin-Lin Wang. et al. Role of calcitonin gene-related peptide in pain regulation in the parabrachial nucleus of naive rats and rats with neuropathic pain. Toxicol Appl Pharm. 2021 Mar;414:115428  Rat.  
[IF=2.605] Pauza AG et al. Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease. (2018) Autonomic Neuroscience.Sep 18. pii: S1566-0702(18)30176-0  IF ;  Human.  
研究領域 細胞生物  免疫學  神經生物學  信號轉導  G蛋白偶聯受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CGRPR1: 281-380/461 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit:
Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominantly expressed in the lung and heart.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

SWISS:
Q16602

Gene ID:
10203

Database links:

Entrez Gene: 10203 Human

Entrez Gene: 54598 Mouse

Entrez Gene: 397172 Pig

Entrez Gene: 25029 Rat

Entrez Gene: 527140 Cow

Omim: 114190 Human

SwissProt: Q16602 Human

SwissProt: Q9R1W5 Mouse

SwissProt: Q8WN93 Pig

SwissProt: Q63118 Rat

Unigene: 470882 Human

Unigene: 11202 Rat



產品圖片
Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Mouse Heart tissue lysates Primary: Anti-CALCRL (bs-1860R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 50 kDa
Sample: Lane 1: Rat Lung tissue lysates Primary: Anti-CALCRL (bs-1860R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 53 kDa
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