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GRM4 Rabbit pAb (bs-1894R)  
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產品編號 bs-1894R
英文名稱 GRM4 Rabbit pAb
中文名稱 促代謝型谷氨酸受體4抗體
別    名 G protein coupled receptor family C group 1 member D; G protein coupled receptor GRM 4; G protein coupled receptor GRM4; Glutamate receptor metabotropic 4; GPRC 1D; GPRC1D; GRM 4; GRM4; GRM4_HUMAN; Metabotropic glutamate receptor 4; mGlu 4; mGlu R4; mGlu4; mGluR 4; mGluR4.  
研究領域 免疫學  神經生物學  細胞凋亡  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 102 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRM4: 301-400/912 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Subunit:
Interacts with PICK1

Subcellular Location:
Cell membrane.

Tissue Specificity:
Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Similarity:
Belongs to the G-protein coupled receptor 3 family.

SWISS:
Q14833

Gene ID:
2914

Database links:

Entrez Gene: 2914 Human

Entrez Gene: 268934 Mouse

Entrez Gene: 24417 Rat

Omim: 604100 Human

SwissProt: Q14833 Human

SwissProt: Q68EF4 Mouse

SwissProt: P31423 Rat

Unigene: 429018 Human



產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with GRM4 polyclonal antibody, unconjugated (bs-1894R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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