97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
99精品在线免费视频,日日夜夜精品视频天天综合网,国产精品国产三级国产aⅴ无密码
首頁 > 產品中心 > 一抗 > 產品信息
Ankyrin G Rabbit pAb (bs-2415R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2415R
英文名稱 Ankyrin G Rabbit pAb
中文名稱 錨定蛋白G抗體
別    名 ANK-3; ANK 3; ANK3; ANK3_HUMAN; ankyrin 3(G); Ankyrin 3, node of Ranvier(ankyrin G); Ankyrin 3, node of Ranvier; Ankyrin G119; Ankyrin-3; Ankyrin-G; brain specific ankyrin G; CHANK3.  
研究領域 神經生物學  信號轉導  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產品應用 Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 481/220 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ankyrin G: 1001-1200/4377 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq]
mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Function:
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments.

Subunit:
Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity).

Tissue Specificity:
Expressed in brain, neurons and other tissues.

DISEASE:
Note=Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility.

Similarity:
Contains 23 ANK repeats.
Contains 1 death domain.
Contains 2 ZU5 domains.

SWISS:
Q12955

Gene ID:
288

Database links:

Entrez Gene: 288 Human

Entrez Gene: 11735 Mouse

Entrez Gene: 361833 Rat

Omim: 600465 Human

SwissProt: Q12955 Human

SwissProt: G5E8K5 Mouse

SwissProt: Q4U206 Mouse

Unigene: 499725 Human

Unigene: 235960 Mouse

Unigene: 202383 Rat



錨定蛋白G是一個分子量在480KDa大分子細胞內蛋白。 錨蛋白(ankyrin)錨蛋白屬于聯結蛋白家族,廣泛存在于各種組織細胞中。錨蛋白連接整合膜蛋白到細胞骨架蛋白網絡,在多種細胞功能活動中起關鍵作用,參與機體生長、發育、細胞內蛋白轉運、細胞極性的建立和維持、細胞黏附、信號傳導以及mRNA轉錄等。
產品圖片
Blank control:Hela. Primary Antibody (green line): Rabbit Anti-Ankyrin G antibody (bs-2415R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 2μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 两个人看的www免费 国产一区二区三区18 | 久久九九视频 | 成年人免费在线看网站 | 免费人成又黄又爽又色 | 妖精视频一区 | 黑人巨茎大战欧美白妇 | 成人av专区| 国产a网站 | 看免费的毛片 | 国产片在线观看 | 欲色综合 | 欧美诱惑一区 | 中文字幕1区2区 | 国产高清免费在线播放 | 狠狠爱ADY亚洲色 | 无码人妻丰满熟妇区毛片 | 日本精品一区二区三区四区 | 美女扒开腿让男人桶爽网站 | 国产99久久亚洲综合精品西瓜tv | 狠狠狠干 | 99久久免费国产精精品 | 91精品一区二区三区在线观看 | 伊人青青久久 | 性猛交xxxx乱大交3 | 无码人妻一区二区三区AV | 国产精品久久久久7777婷婷 | 久久精品国产第一区二区三区 | 国产在线视频在线观看 | av天堂永久资源网av天堂 | 亚洲欧美第一成人网站7777 | 欧美亚洲第一页 | 麻豆视频一区二区三区 | 久热精品视频在线观看 | 宝宝好涨水快流出来免费视频 | 亚洲一区二区三区视频在线 | 亚洲亚洲人成综合丝袜图片 | 午夜a毛片| 久久久久国产一级毛片 | 久久青青草原国产精品最新片 | 亚洲网一区二区三区 | 久草在线手机视频 |