97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产高清黄色在线观看,日韩精品二,色噜噜一区二区
首頁 > 產品中心 > 一抗 > 產品信息
Phospho-CDC42 (Ser71) Rabbit pAb (bs-3369R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-3369R
英文名稱 Phospho-CDC42 (Ser71) Rabbit pAb
中文名稱 磷酸化細胞分化周期CDC42蛋白抗體
別    名 CDC 42; CDC42Hs; Cell division control protein 42 homolog; Cell division cycle 42; Cell division cycle 42 isoform 1; Cell division cycle 42 isoform 2; dJ224A6.1.1; dJ224A6.1.2; G25K; G25K GTP binding protein; Growth regulating protein; GTP binding protein 25kD; Small GTP binding protein CDC42; CDC42_HUMAN.  
Specific References  (1)     |     bs-3369R has been referenced in 1 publications.
[IF=2.049] Lei Q et al. HEV ORF3 down‐regulates CD14 and CD64 to impair macrophages phagocytosis through inhibiting JAK/STAT pathway. Journal of Medical Virology. 2019.  WB ;  Human.  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 ICC/IF=1:100
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDC42 around the phosphorylation site of Ser71: PL(p-S)YP 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].

Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Subunit:
The GTP-bound form interacts with CCPG1. Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody.

Post-translational modifications:
AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.

Similarity:
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

SWISS:
P60953

Gene ID:
998

Database links:

Entrez Gene: 998 Human

Entrez Gene: 12540 Mouse

Entrez Gene: 64465 Rat

Omim: 116952 Human

SwissProt: P60953 Human

SwissProt: P60766 Mouse

SwissProt: Q8CFN2 Rat



Cdc42,是細胞骨架和細胞極化的重要調節蛋白,在減數分裂和卵母細胞成熟過程中有重要的作用,尤其在細胞分化,遷移過程中起到一定的作用,目前在腫瘤研究中得到了重視。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 超碰福利久久 | xxxxx黄色片 国产一二三在线观看 | 色综合一区 | 一女三男做2爱A片免费 | 黑人巨大两根一起挤进交换 | 在线观看免费一区 | 国产精品嫩草99av在线 | 亚洲欧美第一成人网站7777 | 中文字幕一区二区日韩精品绯色 | 欧美爆操| 亚洲国产精品成人av | 国精产品一区二区三区四区 | 麻豆www传媒入口 | 北条麻妃国产九九九精品视频 | 成人一区二区三区久久精品嫩草 | 亚洲国产精品久久亚洲精品大牛 | 少妇在线看www | 豪放美女大兵 | 欧美精品中文 | 77久久 | 曰本A级毛片无卡免费视频 久久热这里只有精品在线观看 | 亚洲狠狠婷婷久久久四季av | 亚洲狠狠婷婷久久久四季av | 中文1区2区3区 | 被公侵犯的漂亮人妻 | 精品卡一卡二卡3卡高清乱码 | 麻豆av资源| 99这里有精品视频 | 欧美日韩亚洲中文字幕一区二区三区 | 成人片黄色大片 | a级一级毛片 | av观看免费 | 国内揄拍国内精品少妇国语 | 成人短篇合集t×t | 99热网| 美女被久久久 | 四虎av无码专区亚洲av | 久久不见久久见中文字幕免费 | 国产成人8x人网站视频 | av蜜臀 | 国产精品无套内射迪丽热巴 |