97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久免费成人精品视频,欧美全黄,在线观看免费福利
首頁 > 產品中心 > 一抗 > 產品信息
phospho-ATF2 (Ser62 / Ser44) Rabbit pAb (bs-5170R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-5170R
英文名稱 phospho-ATF2 (Ser62 / Ser44) Rabbit pAb
中文名稱 磷酸化活化復制因子2抗體
別    名 ATF2(phospho S62+S44); ATF2(phospho-Ser44); ATF2(phospho Ser44); ATF2(phospho S44); p-ATF2(S44); p-ATF2(Ser44); CREB 2; HB 16; Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 55 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse ATF2 around the phosphorylation site of Ser44 / Ser62 (human): ND(p-S)VI 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Function:
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.

Subunit:
Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

Subcellular Location:
Nucleus.

Tissue Specificity:
Abundant expression seen in the brain.

Post-translational modifications:
Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4.

Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
Contains 1 C2H2-type zinc finger.

SWISS:
P15336

Gene ID:
1386

Database links:

Entrez Gene: 1386 Human

Entrez Gene: 100047997 Mouse

Entrez Gene: 11909 Mouse

Entrez Gene: 81647 Rat

Omim: 123811 Human

SwissProt: P15336 Human

SwissProt: P16951 Mouse

SwissProt: Q00969 Rat

Unigene: 592510 Human

Unigene: 209903 Mouse

Unigene: 9825 Rat



產品圖片
Sample: Cerebrum (Mouse)Lysate at 40 ug Cerebellum (Mouse)Lysate at 40 ug Primary: Anti-p-ATF2 (Ser44) (bs-5170R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 55kD Observed band size: 55kD
Sample: Liver (Mouse)Lysate at 40 ug Pancreas (Mouse)Lysate at 40 ug Primary: Anti-p-ATF2 (Ser44)(bs-5170R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 55kD Observed band size: 55kD
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-ATF2 (Ser62 Ser44)) Polyclonal Antibody, Unconjugated (bs-5170R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品一区二区在线 | 性欧美视频一区二区三区 | 一区二区三区日韩一区二区中文 | 草逼一级片 | 国产精品日韩AV在线播放 | 中文字幕免费久久 | 天堂VA视频一区二区 | 9191视频 | 夜夜高潮夜夜爽精品av免费的 | 国产av无码专区亚洲avjulia | 国外精品久久久蜜桃免费全文阅读 | 国产网站观看 | 老师粉嫩小泬喷水视频90 | 国产精品久久不射 | 日韩高清一级 | 亚洲AV无码之国产精品 | 两个人的WWW免费视频 | 久久久999国产视频 成人综合久久综合 | 九九日视频 | 亚洲美国产亚洲AV | 男人放进女人阳道动态图 | 国产视频不卡一区 | 成人在色线视频在线观看免费大全 | 欧美在线播放成人a | 91亚洲影院 | 一级做a爰片性色毛片是免费 | 男男网站18禁免费 | 国产成人精品区一区二区不卡 | 欧美日韩国产高清 | 国产日韩视频在线播放 | 精品久久久久久久人人人人传媒 | 免费无遮挡色视频网站 | 精品综合久久久久久888蜜芽 | 色综合精品无码一区二区三区 | 91精品国产综合久久久久久丝袜 | 二区在线观看 | 免费精品久久久久久久一区二区 | 久久久99精品免费观看乱色 | 欧美顶级毛片在线看 | 91在线小视频 | 黄色视网站 |