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phospho-DOK1 (Tyr398) Rabbit pAb (bs-5290R)  
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產品編號 bs-5290R
英文名稱 phospho-DOK1 (Tyr398) Rabbit pAb
中文名稱 磷酸化D酪氨酸激酶衰減蛋白1抗體
別    名 DOK1(phospho Y398); DOK1(phospho Tyr398); p-DOK1(phospho Y398); docking protein 1(downstream of tyrosine kinase 1); Docking protein 1(p62(dok))(Downstream of tyrosine kinase 1)(pp62).; docking protein 1 62kD(downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62.  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  免疫學  信號轉導  細胞凋亡  G蛋白偶聯受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr398: EG(-Y)EL 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Subunit:
Interacts with ABL1. Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.

Subcellular Location:
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.

Tissue Specificity:
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.

Post-translational modifications:
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN.
Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
Isoform 3 contains a N-acetylmethionine at position 1.

Similarity:
Belongs to the DOK family. Type A subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

SWISS:
Q99704

Gene ID:
1796

Database links:

Entrez Gene: 1796 Human

Entrez Gene: 13448 Mouse

Entrez Gene: 312477 Rat

Omim: 602919 Human

SwissProt: Q99704 Human

SwissProt: P97465 Mouse

SwissProt: Q4QQV2 Rat

Unigene: 103854 Human

Unigene: 156 Mouse

Unigene: 117974 Rat



產品圖片
Sample: Spleen (Mouse) Lysate at 40 ug Lymph node (Mouse) Lysate at 40 ug Primary: Anti- phospho-DOK1 (Tyr398) (bs-5290R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 52 kD
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