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phospho-FXYD1 (Ser83) Rabbit pAb (bs-5348R)  
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產品編號 bs-5348R
英文名稱 phospho-FXYD1 (Ser83) Rabbit pAb
中文名稱 磷酸化磷酸神經膜抗體
別    名 FXYD1(phospho S83); FXYD1(phospho Ser83); p-FXYD1(phospho S83); FXYD domain containing ion transport regulator 1; phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1.  
產品類型 磷酸化抗體 
研究領域 免疫學  神經生物學  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 10 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser83: RS(p-S)IR 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.

Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.

Post-translational modifications:
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK.
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.

Similarity:
Belongs to the FXYD family.

SWISS:
O00168

Gene ID:
5348

Database links:

Entrez Gene: 476487 Dog

Entrez Gene: 5348 Human

Entrez Gene: 56188 Mouse

Entrez Gene: 58971 Rat

Omim: 602359 Human

SwissProt: P56513 Dog

SwissProt: O00168 Human

SwissProt: Q9Z239 Mouse

SwissProt: O08589 Rat

Unigene: 442498 Human



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