97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲天堂免费观看,蜜桃av免费看,99高清国产清纯学生在线观看
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
VAV1 Rabbit pAb (bs-4167R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4167R
英文名稱(chēng) VAV1 Rabbit pAb
中文名稱(chēng) 鳥(niǎo)苷酸轉(zhuǎn)換因子VAV1抗體
別    名 Oncogene vav; p95Vav; Protooncogene vav; Proto-oncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; Vav proto-oncogene; VAV_HUMAN .  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human (predicted: Mouse,Rat,Pig,Cow,Horse)
產(chǎn)品應(yīng)用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 98 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV1: 741-845/845 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

Function:
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subunit:
May interact with CCPG1. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. Interacts with THEMIS2. Interacts with HCK. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54.

Tissue Specificity:
Widely expressed in hematopoietic cells but not in other cell types.

Post-translational modifications:
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN.

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

SWISS:
P15498

Gene ID:
7409

Database links:

Entrez Gene: 7409 Human

Entrez Gene: 22324 Mouse

Entrez Gene: 25156 Rat

Omim: 164875 Human

SwissProt: P15498 Human

SwissProt: P27870 Mouse

SwissProt: P54100 Rat

Unigene: 116237 Human

Unigene: 248172 Mouse

Unigene: 48861 Rat



Vav1蛋白是特異于造血細(xì)胞表達(dá)的鳥(niǎo)苷酸轉(zhuǎn)換因子,它參與了多種免疫細(xì)胞如T細(xì)胞,B細(xì)胞,巨噬細(xì)胞,自然殺傷性細(xì)胞等的胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo),發(fā)揮著重要作用. Vav1主要參與T細(xì)胞信號(hào)傳導(dǎo)途徑,傳導(dǎo)信號(hào)激活鈣流、細(xì)胞外信號(hào)調(diào)節(jié)激酶(ERK)以及轉(zhuǎn)錄因子NFκB。Vav1蛋白在T細(xì)胞生長(zhǎng)發(fā)育、成熟T細(xì)胞激活、細(xì)胞因子合成及細(xì)胞骨架活動(dòng)中發(fā)揮重要作用。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 中日黄色一级片 | 无码专区—va亚洲v专区 | wwwwww日本 | 真人在线观看色网视频 | HTTPWWW色午夜COM曰本 | 日本一区视频在线观看 | 精品一区二区中文字幕 | 免费在线观看h视频 | 无遮无挡爽爽免费视频 | 亚洲AV成人WWW永久无码精品 | 日韩毛片免费视频一级特黄 | 久久er综合 | 大地资源免费更新在线播放 | 国产最全免费视频在线 | 中文字幕在线中文 | va久久久久精码专区 | 国产主播一区二区三区 | 国产香蕉青春草原久久 | 无码人妻精品一区二区在线视频 | 人妻系列无码专区无码专区 | 五月丁香六月激情综合在线视频 | 蜜桃传免费看片www 蜜臀av免费一区二区三区水牛 | 牲高潮99爽久久久久777 | 日韩精品视频在线观看视频 | 夜夜草专业av导航 | 成人A片产无码免费奶头 | 久久久精品欧美 | 色综合久久精品 | 国内久久久 | 国产精品一区二区久久精品爱微奶 | 香港三级日本三级韩国三级 | 变形金刚之超能勇士免费观看 | 国产精成人品 | 日本激情视频一区 | ⅹxxxxhd亚洲日本hd | 九九久久精品国产 | www.黄色网址.com | 久久综合九色综合97网 | 成人午夜做爰视频免费看 | 九九热线视频只有这里最精品 | 久久天堂一区二区三区 |