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CDKN2C/p18 INK4c Rabbit pAb (bs-4270R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-4270R
英文名稱 CDKN2C/p18 INK4c Rabbit pAb
中文名稱 細胞周期蛋白依賴性激酶抑制劑2C抗體
別    名 CDK6 inhibitor p18; CDKN 2C; CDKN 6; CDKN2C; CDKN6; CDN2C_HUMAN; Cyclin dependent inhibitor; Cyclin dependent kinase 4 inhibitor C; Cyclin dependent kinase 6 inhibitor; Cyclin dependent kinase 6 inhibitor p18; Cyclin dependent kinase inhibitor 2C(p18 inhibits CDK4); Cyclin dependent kinase inhibitor 2C; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; INK4C; OTTHUMP00000046546; p18; p18 inhibits CDK4; p18 INK4c; p18 INK6; p18-INK4c; p18-INK6.  
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 18 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDKN2C: 101-168/168 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 p18 INK4c is a specific inhibitor of cdk4 / cdk6 (it interacts strongly with CDK6 and weakly with CDK4), and is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S phase. Highest expression levels are found in skeletal muscle, but it is also found in the pancreas and heart.

Function:
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Subunit:
Heterodimer of p18 with CDK6.

Tissue Specificity:
Highest levels found in skeletal muscle. Also found in pancreas and heart.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.

SWISS:
P42773

Gene ID:
1031

Database links:

Entrez Gene: 469319 Chimpanzee

Entrez Gene: 505691 Cow

Entrez Gene: 475359 Dog

Entrez Gene: 101125732 Gorilla

Entrez Gene: 1031 Human

Entrez Gene: 12580 Mouse

Entrez Gene: 29658 Rat

Entrez Gene: 711877 Rhesus monkey

Omim: 603369 Human

SwissProt: P42773 Human

SwissProt: Q60772 Mouse

Unigene: 525324 Human

Unigene: 728783 Human

Unigene: 1912 Mouse

Unigene: 63865 Rat



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