97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久精品3,成人国产福利a无限看,色18美女社区
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
SUV39H1 Rabbit pAb (bs-5708R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5708R
英文名稱 SUV39H1 Rabbit pAb
中文名稱 組蛋白H3 K9甲基轉(zhuǎn)移酶抗體
別    名 SUV91_HUMAN; Histone-lysine N-methyltransferase SUV39H1; KMT1A; UV39H; EC:2.1.1.355; Histone H3-K9 methyltransferase 1(H3-K9-HMTase 1); Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1(Su(var)3-9 homolog 1); SUV39H1 histone lysine methyltransferase; MG44; SUV39H; H3-K9-HMTase 1;  
Specific References  (1)     |     bs-5708R has been referenced in 1 publications.
[IF=4.374] Ji Lina. et al. A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma. HUM CELL. 2023 Mar;:1-17  IHC ;  Human.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Cow,Dog)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 48 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KMT1A: 211-310/412 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

Subunit:
nteracts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity (By similarity).

Subcellular Location:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.

Post-translational modifications:
Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.
Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition.

Similarity:
Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.
Contains 1 chromo domain.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

SWISS:
O43463

Gene ID:
6839

Database links:

Entrez Gene: 6839 Human

Entrez Gene: 20937 Mouse

Entrez Gene: 302553 Rat

Omim: 300254 Human

SwissProt: O43463 Human

SwissProt: O54864 Mouse

Unigene: 522639 Human

Unigene: 479743 Mouse

Unigene: 9244 Mouse



版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 四虎影院最新 | 中文字幕天堂av | 粗暴进入娇小呻吟痛呼 | 911精品美国片911久久久 | 无码专区国产精品第一页 | 国产系列视频二区 | 日本中文字幕日韩精品免费 | 精品乱子伦一区日本午夜 | 亚洲好骚综合 | 日本在线看片免费人成视频 | 中文字幕一区二区在线播放 | 精品精品国产高清a毛片 | 巨大欧美黑人XXXXBBBB | 激情aⅴ欧美一区二区欲海潮 | 99精品成人无码A片观看 | 欧美日韩亚洲天堂 | 无码人妻丰满熟妇区毛片 | 国内免费视频成人精品 | 国产高清一区二区三区视频 | 乱人伦中文视频在线观看 | 一区不卡| a国产亚洲欧美精品一区在线观看 | 欧美日韩高清一区二区三区 | 精品国产伦一区二区三区 | 日本一区免费看 | 免费午夜网站 | 女人和男人视频网站 | 无码专区国产精品第一页 | 色综合精品无码一区二区三区 | 69一区二区| 伊人免费视频 | 麻豆免费观看 | 亚洲欧美精 | 校园春色另类小说 | 免费一级片网址 | 伊人插插插| 国产二区自拍 | 国产免费丝袜调教视频 | 大陆av在线播放 | 日韩毛片网站 | 欧美日韩国产色综合视频 |