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CD105 Rabbit pAb (bs-4609R)  
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產品編號 bs-4609R
英文名稱 CD105 Rabbit pAb
中文名稱 內皮糖蛋白抗體
別    名 END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen; EGLN_HUMAN; AI528660; AI662476; S-endoglin; SN6.  
Specific References  (15)     |     bs-4609R has been referenced in 15 publications.
[IF=9.776] Ruijing Zhao. et al. Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury. J Control Release. 2022 May;345:214  FC ;  Human.  
[IF=6.832] Park, Hyeri. et al. Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway. Stem Cell Res Ther. 2022 Dec;13(1):1-16  WB ;  Rat.  
[IF=4.396] Shao F et al. Multiboosting of cancer immunotherapy by a core-shell delivery system. Mol Pharm. 2020 Jan 6;17(1):338-348.  IHC-P ;  Mouse.  
[IF=4.034] Wang YL et al. Preinduction with bone morphogenetic protein-2 enhances cardiomyogenic differentiation of c-kit+ mesenchymal stem cells and repair of infarcted myocardium.Int J Cardiol. 2018 Aug 15;265:173-180.  FCM ;  Rat.  
[IF=3.998] Gae Won Parket al. Topical cell-free conditioned media harvested from adipose tissue-derived stem cells promote recovery from corneal epithelial defects caused by chemical burns. Sci Rep . 2020 Jul 24;10(1):12448.  FCM ;  rat.  
[IF=3.24] Enoch Odame Anto. et al. Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia. Plos One. 2022 Mar;17(3):e0265717  IHC ;  Human.  
[IF=2.94] Wang, Kai, et al. "Over-expression of Mash1 improves the GABAergic differentiation of bone marrow mesenchymal stem cells< i> in vitro." Brain Research Bulletin (2013).  FCM ;  Rat.  
[IF=2.88] Long, Qianfa, et al. "Genetically engineered bone marrow mesenchymal stem cells improve functional outcome in a rat model of epilepsy." Brain Research (2013).  Rat.  
[IF=2.51] Gao, Qian, et al. "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." Molecular biology reports 39.5 (2012): 5791-5804.  Rat.  
[IF=2.21] Ziya Yurtal. et al. Protective and Therapeutic Effects of Bovine Amniotic Fluids Collected in Different Trimesters on The Epidural Fibrosis After Experimental Laminectomy in Rats. WORLD NEUROSURG. 2023 Jan;:  IHC ;  Rat.  
[IF=2.02] Zhao, Min, et al. "Placental expression of VEGF is increased in pregnancies with hydatidiform mole: Possible association with developing very early onset preeclampsia." Early Human Development (2013).  WB ;  Human.  
[IF=1.527] Hassanzadeh?H et al. Using paracrine effects of Ad-MSCs on keratinocyte cultivation and fabrication of epidermal sheets for improving clinical applications. Cell Tissue Bank. 2018 Dec;19(4):531-547.  FCM ;  Human.  
[IF=1.23] Bidkhori, Hamid Reza, et al. "Chemically primed bone-marrow derived mesenchymal stem cells show enhanced expression of chemokine receptors contributed to their migration capability." Iranian Journal of Basic Medical Sciences 19.1 (2016): 14-19.  Human.  
[IF=1.169] Heirani-Tabasi, Asieh, et al. "Chemokine Receptors Expression in MSCs: Comparative Analysis in Different Sources and Passages."Tissue Eng Regen Med. 2017 Sep 19;14(5):605-615.  FCM ;  Human.  
[IF=0] Bach et al. Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside. (2018) Oncotarget. 9:26507-26526  FC ;  canine.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  干細胞  細胞膜受體  細胞表面分子  血管內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 70 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD105/Endoglin: 58-110/625 <Extracellular>
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Function:
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.

Subunit:
Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Endoglin is restricted to endothelial cells in all tissues except bone marrow.

DISEASE:
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.

SWISS:
P17813

Gene ID:
2022

Database links:

Entrez Gene: 2022 Human

Entrez Gene: 13805 Mouse

Entrez Gene: 497010 Rat

Omim: 131195 Human

SwissProt: P17813 Human

SwissProt: Q63961 Mouse

Unigene: 76753 Human

Unigene: 225297 Mouse



CD105(Endoglin):CD105是一種分子量為180kDa的存在于細胞表面的同源二聚體跨膜糖蛋白,是TGF-β受體復合物的組成部分,是TGF-β的附屬受體,能與多種TGF-β超家族成員結合尤其與TGF-β1、TGF-β3有很高的親和力,調節TGF-βs與其受體結合而參與信號傳導,是內皮細胞增殖相關膜抗原,在培養的高增殖活性內皮細胞和許多惡性腫瘤組織血管內皮細胞中高表達,參與血管生成,但其在血管生成調節中的作用機制尚未闡明。CD105基因定位于人9號染色體,是Ⅰ型遺傳性出血性毛細血管擴張癥的相關基因。CD105基因敲除小鼠胚胎因血管生成缺陷而于受精后平均11.5天死亡,故有學者認為,CD105可能與血管生成啟動有關,可用于標記腫瘤新生血管。 Endoglin是內皮細胞表面與細胞增殖相關的膜抗原,也是轉化生長因子β超家族受體復合物成分之一。其具有調節內皮細胞對TGF的反應、促內皮細胞增殖和促血管形成等功能,與腫瘤血管的發生密切相關。近年來,Endoglin在腫瘤診斷、判斷預后和療效及抗腫瘤血管靶向治療等方面的作用得到重視。姬,2017.1.15;
產品圖片
Paraformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-4609R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-4609R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-4609R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Blank control:Hela. Primary Antibody (green line): Rabbit Anti-CD105 antibody (bs-4609R) Dilution: 2ug/Test; Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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