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CDKN3 Rabbit pAb (bs-5743R)  
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50ul/1180.00元
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產品編號 bs-5743R
英文名稱 CDKN3 Rabbit pAb
中文名稱 細胞周期蛋白依賴性激酶抑制蛋白3抗體
別    名 Cdk associated protein phosphatase; CDI1; CDK2 associated dual specificity phosphatase; CIP2; Cyclin dependent kinase inhibitor 3; Cyclin dependent kinase interactor 1; Cyclin dependent kinase-interacting protein 2; KAP1; Kinase associated phosphatase.  
Specific References  (1)     |     bs-5743R has been referenced in 1 publications.
[IF=12.822] Sha Li. et al. Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma. J ADV RES. 2023 Jan;:  IHC ;  Mouse.  
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDKN3: 51-150/212 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CDKN3 is a second dual specificity phosphatase that interacts with cyclin dependent kinases.The ability of CDKN3 to bind multiple cyclin-dependent kinases suggests that it may be a critical control element in cell cycle regulation, presumably by regulating the phosphorylation state of a Cdk or Cdk-associated protein.

Function:
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.

Subunit:
Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.

Subcellular Location:
Cytoplasm, perinuclear region.

DISEASE:
Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].

Similarity:
Belongs to the protein-tyrosine phosphatase family.

SWISS:
Q16667

Gene ID:
1033

Database links:

Entrez Gene: 1033 Human

Entrez Gene: 72391 Mouse

Entrez Gene: 397589 Pig

Entrez Gene: 289993 Rat

Omim: 123832 Human

SwissProt: Q16667 Human

SwissProt: Q810P3 Mouse

SwissProt: Q9MYN5 Pig

SwissProt: B2RZ50 Rat

Unigene: 84113 Human

Unigene: 272394 Mouse

Unigene: 107220 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (human Prostate Tumor); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CDKN3) Polyclonal Antibody, Unconjugated (bs-5743R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CDKN3) Polyclonal Antibody, Unconjugated (bs-5743R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human cervical carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CDKN3) Polyclonal Antibody, Unconjugated (bs-5743R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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