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CRABP2 Rabbit pAb (bs-6038R)  
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50ul/1180.00元
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200ul/2800.00元
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產(chǎn)品編號 bs-6038R
英文名稱 CRABP2 Rabbit pAb
中文名稱 細胞維甲酸結(jié)合蛋白2抗體
別    名 Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; CRABP II; CRABPII; CRABP 2; CRABP-2; RBP6; RABP2_HUMAN.  
研究領(lǐng)域 腫瘤  細胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Dog,GuineaPig)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 16 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRABP2: 51-138/138 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.

Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Subunit:
Interacts with RXR and RARA. Interacts with importin alpha.

Subcellular Location:
Cytoplasm. Endoplasmic reticulum. Nucleus.

Post-translational modifications:
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.

Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

SWISS:
P29373

Gene ID:
1382

Database links:

Entrez Gene: 1382 Human

Entrez Gene: 12904 Mouse

Entrez Gene: 29563 Rat

Omim: 180231 Human

SwissProt: P29373 Human

SwissProt: P22935 Mouse

SwissProt: P51673 Rat

Unigene: 405662 Human

Unigene: 4757 Mouse

Unigene: 11333 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse esophagus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRABP2) Polyclonal Antibody, Unconjugated (bs-6038R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat esophagus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRABP2) Polyclonal Antibody, Unconjugated (bs-6038R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat skin); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRABP2) Polyclonal Antibody, Unconjugated (bs-6038R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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