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PIG3 Rabbit pAb (bs-6143R)  
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產(chǎn)品編號(hào) bs-6143R
英文名稱 PIG3 Rabbit pAb
中文名稱 p53誘導(dǎo)蛋白3抗體
別    名 p53 induced gene 3 protein; p53-induced gene 3 protein; Putative quinone oxidoreductase; quinone oxidoreductase homolog; TP53I3; tumor protein p53 inducible protein 3; Tumor protein p53-inducible protein 3; QORX_HUMAN.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIG3/TP53I3: 151-250/332 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene (from EntrezGene).

Function:
May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).

Subunit:
Homodimer.

Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

SWISS:
Q53FA7

Gene ID:
9540

Database links:

Entrez Gene: 9540 Human

Omim: 605171 Human

SwissProt: Q53FA7 Human

Unigene: 50649 Human



產(chǎn)品圖片
Sample: Lane 1: Human HeLa cell lysates Lane 2: Human HepG2 cell lysates Lane 3: Human A549 cell lysates Lane 4: Human MCF-7 cell lysates Primary: Anti-PIG3 (bs-6143R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa
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