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TROP2 Rabbit pAb (bs-6198R)  
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產(chǎn)品編號 bs-6198R
英文名稱 TROP2 Rabbit pAb
中文名稱 腫瘤相關鈣信號傳感器2抗體
別    名 Cell surface glycoprotein Trop 2; Cell surface glycoprotein Trop-2; Cell surface glycoprotein Trop2; Epithelial glycoprotein 1; GA733 1; GA7331; M1S 1; M1S1; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733 1; Pancreatic carcinoma marker protein GA733-1; Pancreatic carcinoma marker protein GA7331; TACD 2; TACD2_HUMAN; TACSTD 2; TACSTD2; Trop 2; Trop2; Tumor associated calcium signal transducer 2 precursor; Tumor-associated calcium signal transducer 2.  
研究領域 腫瘤  信號轉(zhuǎn)導  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 33 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TROP2/TACD2: 221-322/322 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Function:
May function as a growth factor receptor.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Placenta, pancreatic carcinoma cell lines.

Post-translational modifications:
The N-terminus is blocked.

DISEASE:
Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the EPCAM family.
Contains 1 thyroglobulin type-1 domain.

SWISS:
P09758

Gene ID:
4070

Database links:

Entrez Gene: 4070 Human

Entrez Gene: 56753 Mouse

Entrez Gene: 494343 Rat

Omim: 137290 Human

SwissProt: P09758 Human

SwissProt: Q8BGV3 Mouse

SwissProt: Q6P9Z6 Rat

Unigene: 23582 Human

Unigene: 439913 Mouse

Unigene: 24809 Rat



產(chǎn)品圖片
Sample: A549 Cell (Human) Lysate at 40 ug Primary: Anti-TROP2 (bs-6198R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 35 kD
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