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KIST Rabbit pAb (bs-6260R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-6260R
英文名稱 KIST Rabbit pAb
中文名稱 絲氨酸/蘇氨酸蛋白激酶KIST抗體
別    名 kinase interacting with leukemia-associated gene(stathmin); Kinase interacting with stathmin; KIS; KIS protein kinase; KIST; Serine threonine protein kinase Kist; Serine/threonine-protein kinase Kist; U2AF homology motif(UHM) kinase 1; U2AF homology motif kinase 1; UHMK1; UHMK1_HUMAN.  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  轉錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 47 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIST/UHMK1: 331-419/419 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Subunit:
Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).

Subcellular Location:
Nucleus. Note=Mostly nuclear (By similarity).

Tissue Specificity:
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 RRM (RNA recognition motif) domain.

SWISS:
Q8TAS1

Gene ID:
127933

Database links:

Entrez Gene: 127933 Human

Entrez Gene: 16589 Mouse

Entrez Gene: 246332 Rat

Omim: 608849 Human

SwissProt: Q8TAS1 Human

SwissProt: P97343 Mouse

SwissProt: Q63285 Rat

Unigene: 127310 Human

Unigene: 209150 Mouse

Unigene: 389214 Mouse

Unigene: 89229 Rat



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