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Cyclin B2 Rabbit pAb (bs-6656R)  
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50ul/1180.00元
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產品編號 bs-6656R
英文名稱 Cyclin B2 Rabbit pAb
中文名稱 周期素B2抗體
別    名 Cyclin-B2; CycB2; G2 mitotic specific cyclin B2; G2/mitotic specific cyclin B2; CCNB2_HUMAN.  
Specific References  (2)     |     bs-6656R has been referenced in 2 publications.
[IF=2.65] Ruoyang Lin. et al. Inhibitory Effects of Rabdosia rubescens in Esophageal Squamous Cell Carcinoma: Network Pharmacology and Experimental Validation. EVID-BASED COMPL ALT. 2022 Nov 10;2022:2696347  WB ;  Human.  
[IF=2.08] Zhang, Jihong, et al. "Interleukin 18 augments growth ability via NF-κB and p38/ATF2 pathways by targeting cylin B1, cyclin B2, cylin A2, and Bcl-2 in BRL-3A rat liver cells." Gene (2015).  WB ;  Rat.  
研究領域 細胞生物  免疫學  細胞周期蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 45 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin B2: 221-320/398 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Cyclin B2 belongs to a the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin B2 has been shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.

Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Subunit:
Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.

SWISS:
O95067

Gene ID:
9133

Database links:

Entrez Gene: 9133 Human

Entrez Gene: 12442 Mouse

Entrez Gene: 363088 Rat

Omim: 602755 Human

SwissProt: O95067 Human

SwissProt: P30276 Mouse

Unigene: 194698 Human

Unigene: 22592 Mouse



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