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PRAME Rabbit pAb (bs-7004R)  
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產品編號 bs-7004R
英文名稱 PRAME Rabbit pAb
中文名稱 黑色素瘤優先表達抗原抗體
別    名 MAPE; Melanoma antigen preferentially expressed in tumors; OIP 4; OIP-4; OIP4; OPA interacting protein 4; Opa interacting protein OIP4; OPA-interacting protein 4; PRAME_HUMAN; Preferentially expressed antigen in melanoma; Preferentially expressed antigen of melanoma; RP23-250F8.3.  
Specific References  (2)     |     bs-7004R has been referenced in 2 publications.
[IF=16.304] Premal D. Lullaet al. The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma.  IHC ;  Human.  
[IF=5.485] Valentina Hoyos. et al. Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer:. THER ADV MED ONCOL. 2022;():  IHC ;  Human.  
研究領域 腫瘤  細胞生物  信號轉導  腫瘤細胞生物標志物  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=0.2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 細胞核 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PRAME: 151-250/509 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Function:
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Subunit:
Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.

Subcellular Location:
Nucleus (Probable). Cell membrane.

Tissue Specificity:
Expressed in testis. Detected in samples of kidney, brain and skin.

Similarity:
Belongs to the PRAME family.
Contains 4 LRR (leucine-rich) repeats.

SWISS:
P78395

Gene ID:
23532

Database links:

Entrez Gene: 23532 Human

SwissProt: P78395 Human



產品圖片
Tissue/cell: mouse lung tissue(Melanoma); 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PRAME Polyclonal Antibody, Unconjugated(bs-7004R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control(blue): Hela Cells(fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice). Primary Antibody: Rabbit Anti-PRAME/AF647 Conjugated antibody (bs-7004R-AF647), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF647(orange) ,used under the same conditions.
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