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FSCN1 Rabbit pAb (bs-6848R)  
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產(chǎn)品編號(hào) bs-6848R
英文名稱 FSCN1 Rabbit pAb
中文名稱 肌動(dòng)蛋白結(jié)合蛋白Fascin抗體
別    名 55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; FAN 1; Fscin1; FAN1; Fascin 1; Fascin; Fascin homolog 1 actin bundling protein(Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1_HUMAN; HSN; p55; Singed(Drosophila) like(sea urchin fascin homolog like); Singed drosophila homolog like; Singed like(fascin homolog sea urchin)(Drosophila); Singed like(fascin homolog sea urchin); Singed like protein; Singed-like protein; SNL; Strongylocentrotus purpuratus.  
Specific References  (1)     |     bs-6848R has been referenced in 1 publications.
[IF=3.91] Dong, Wei-tao, et al. "iTRAQ proteomic analysis of the interactions between Bombyx mori nuclear polyhedrosis virus and silkworm." Journal of Proteomics (2017).  WB ;  Other Species.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Human,Rat,Dog)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 55 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FSCN1: 401-493/493 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.

Function:
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Subunit:
Associates with beta-catenin. Interacts with PLXNB3.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.

Similarity:
Belongs to the fascin family.

SWISS:
Q16658

Gene ID:
6624

Database links:

Entrez Gene: 6624 Human

Entrez Gene: 14086 Mouse

Entrez Gene: 683788 Rat

Omim: 602689 Human

SwissProt: Q16658 Human

SwissProt: Q61553 Mouse

SwissProt: P85845 Rat

Unigene: 118400 Human

Unigene: 289707 Mouse

Unigene: 199526 Rat



Fascin基因?qū)儆趂ascins家族,其蛋白質(zhì)編碼產(chǎn)物是一種結(jié)構(gòu)獨(dú)特、進(jìn)化保守的肌動(dòng)蛋白(actin)交聯(lián)蛋白,位于細(xì)胞膜皺褶、微棘及應(yīng)力纖維,在各種轉(zhuǎn)化細(xì)胞中促使細(xì)胞膜突起并增加細(xì)胞運(yùn)動(dòng)性。近年來研究發(fā)現(xiàn),fascin在許多上皮來源的腫瘤組織細(xì)胞中表達(dá)上調(diào),在腫瘤的進(jìn)展中起重要作用。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Fascin) Polyclonal Antibody, Unconjugated (bs-6848R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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