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GIMAP5 Rabbit pAb (bs-8271R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-8271R
英文名稱 GIMAP5 Rabbit pAb
中文名稱 GTP酶IMAP家族成員5抗體
別    名 HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; FLJ11296; GIMAP 5; GTPase IMAP family member 5; GTPase, IMAP family member 5; immunity-associated nucleotide 5; hIAN5; IAN 5; Immune associated nucleotide 4 like 1; Immunity associated nucleotide 4 like 1 protein; Immunity associated protein 3; GIMA5_HUMAN.  
研究領域 細胞生物  免疫學  信號轉導  t-淋巴細胞  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 35 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIMAP5: 101-200/307 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.

Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome.

Tissue Specificity:
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.

Similarity:
Belongs to the IAN GTP-binding protein family.

SWISS:
Q96F15

Gene ID:
55340

Database links:

Entrez Gene: 55340 Human

Omim: 608086 Human

SwissProt: Q96F15 Human

Unigene: 647079 Human

Unigene: 698139 Human



產品圖片
Sample: U937 (Human) Cell Lysate at 30 ug Primary: Anti-GIMAP5 (bs-8271R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD
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