97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
在线视频精品播放,www.五月天色,中文字幕在线免费看线人
首頁 > 產品中心 > 一抗 > 產品信息
KCNE1 Rabbit pAb (bs-9928R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-9928R
英文名稱 KCNE1 Rabbit pAb
中文名稱 鉀離子通道蛋白家族成員1抗體
別    名 Delayed rectifier potassium channel subunit IsK; Human cardiac delayed rectifier potassium channel protein; IKs producing slow voltage gated potassium channel subunit beta Mink; ISK; JLNS 2; JLNS; JLNS2; KCNE 1; LQT 5; LQT5; Minimal potassium channel; MinK; Potassium voltage gated channel Isk related family member 1; Potassium voltage gated channel Isk related subfamily member 1; Potassium voltage gated channel subfamily E member 1; KCNE1_HUMAN.  
Specific References  (1)     |     bs-9928R has been referenced in 1 publications.
[IF=5.9] Zhao, Jing, et al. "Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications." Basic Research in Cardiology 109.5 (2014): 1-13.  WB ;  Dog.  
研究領域 心血管  神經生物學  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 15 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNE1: 41-129/129 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].

Function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).

Subunit:
Associates with KCNQ1/KVLQT1 and KCNH2/HERG.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.

Post-translational modifications:
Phosphorylation inhibits the potassium current (By similarity).
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.

DISEASE:
Defects in KCNE1 are the cause of Jervell and Lange-Nielsen syndrome type 2 (JLNS2) [MIM:612347]. JLNS2 is an autosomal recessive disorder characterized by congenital deafness, prolongation of the QT interval, syncopal attacks due to ventricular arrhythmias, and a high risk of sudden death.
Defects in KCNE1 are the cause of long QT syndrome type 5 (LQT5) [MIM:613695]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE1 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents.

Similarity:
Belongs to the potassium channel KCNE family.

SWISS:
P15382

Gene ID:
3753

Database links:

Entrez Gene: 3753 Human

Entrez Gene: 16509 Mouse

Entrez Gene: 397331 Pig

Entrez Gene: 25471 Rat

Omim: 176261 Human

SwissProt: P15382 Human

SwissProt: P23299 Mouse

SwissProt: Q9TUH9 Pig

SwissProt: P15383 Rat

Unigene: 121495 Human

Unigene: 299425 Mouse

Unigene: 9734 Rat



版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲一区二区三区在线视频 | 91精品国产综合久久久久久蜜月 | 亚洲色炮av图 | 色综合久久天天综合网 | 香港三级日本三级韩国三级 | 亚洲国产成人精品女人久 | 国产欧美一区二区三区国产幕精品 | 国产一级做a爰片久久 | 色婷婷五月综合亚洲影院 | 狠狠做深爱婷婷久久综合一区 | 91精品国产高清一区二区三密臀 | 国产毛片精品 | 亚洲色大网站WWW永久网站 | 不卡在线一区2区三区 | 一区二区三区精品视频免费看 | 99国产观看免费视频 | 色婷婷狠狠18禁久久yyy☆ | 久久免费视频国产 | 亚色中文 | 一二三四在线观看免费中文在线观看 | 色一情一乱一伦一区二区三区 | 性a一级| 国产九色视频在线观看 | 色一欲一性一乱一区二区三区 | 亚人在线播放国产中文字幕 | 67194中文字幕在线观看日韩 | 国产亚洲精品久久久久久青梅 | 免费观看69xx | 亚洲精品中文字幕乱码4区 一本一道波多野结衣av黑人 | 精品国偷自产在线视频 | 老女人高潮视频 | 老司机福利在线视频 | 国产无遮挡色视频免费观看性色 | 国产性一交一乱一伦一色一情 | 这里只有精品在线观看 | 欧美视频国产 | 欧美老妇视频热 | 日韩一区二区三区在线播放 | 免费v片在线观看 | 99热9| 韩国三级激情吃奶 |