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GIPC-2 Rabbit pAb (bs-8586R)  
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產品編號 bs-8586R
英文名稱 GIPC-2 Rabbit pAb
中文名稱 胞漿區相關蛋白GIPC2抗體
別    名 GIPC 2; GIPC-2 GIPC PDZ domain containing family, member 2; GIPC2; GIPC2_HUMAN; Likely ortholog of mouse semaF cytoplasmic domain associated protein 2; PDZ domain protein GIPC2; PDZ domain-containing protein GIPC2; SemaF cytoplasmic domain associated protein 2; Semaphorin cytoplasmic domain associated protein 2; SEMCAP 2; SEMCAP2.  
Specific References  (1)     |     bs-8586R has been referenced in 1 publications.
[IF=4.136] Min Kang. et al. Increased expression of GIPC2 in colon adenocarcinoma is associated with a favorable prognosis and high levels of immune cell infiltration. ONCOL REP. 2023 Apr;49(4):1-11  IHC ;  Human.  
研究領域 腫瘤  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIPC2: 201-300/315 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GIPC2 is a 315 amino acid protein that localizes to the cytoplasm and contains one PDZ domain. Expressed at high levels in kidney and colon and at lower levels in adult liver, GIPC2 interacts with SEMA5A and is thought to function as a scaffold protein, possibly modulating cell adhesion and growth factor signaling and playing a role in tumorigenesis. The gene encoding GIPC2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Subunit:
Probably interacts with SEMA5A (By similarity). .

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors.

Similarity:
Contains 1 PDZ (DHR) domain.

SWISS:
Q8TF65

Gene ID:
54810

Database links:

Entrez Gene: 54810 Human

Entrez Gene: 54120 Mouse

Entrez Gene: 365960 Rat

SwissProt: Q8TF65 Human

SwissProt: Q9Z2H7 Mouse

SwissProt: Q498D9 Rat

Unigene: 659356 Human

Unigene: 97 Mouse



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GIPC-2) Polyclonal Antibody, Unconjugated (bs-8586R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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