97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
蜜桃传免费看片www,亚洲av无码av日韩av网站,精品久久久久久久久久中出
首頁 > 產品中心 > 一抗 > 產品信息
Caspr2 Rabbit pAb (bs-11129R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-11129R
英文名稱 Caspr2 Rabbit pAb
中文名稱 軸突相關CNTP2蛋白抗體(少突膠質細胞)
別    名 Cell recognition molecule Caspr2; Cntnap2; CNTP2; CNTP2_HUMAN; Contactin-associated protein-like 2.  
研究領域 神經生物學  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Rat
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 145 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Caspr2: 801-900/1331 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adult nervous system possess specialized subcellular structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecule CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.

Function:
May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.

Subunit:
Associates with KCNA2.

Subcellular Location:
Membrane.

Tissue Specificity:
Predominantly expressed in nervous system.

DISEASE:
Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.

Similarity:
Belongs to the neurexin family.
Contains 2 EGF-like domains.
Contains 1 F5/8 type C domain.
Contains 1 fibrinogen C-terminal domain.
Contains 4 laminin G-like domains.

SWISS:
Q9UHC6

Gene ID:
26047

Database links:

Entrez Gene: 26047 Human

Entrez Gene: 66797 Mouse

Omim: 604569 Human

SwissProt: Q9UHC6 Human

SwissProt: Q9CPW0 Mouse

Unigene: 655684 Human

Unigene: 440084 Mouse



版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 中文字幕在线中文字幕二区 | 尤物国精品午夜福利视频 | 欧美成人影片 | 国产系列视频二区 | 大地资源在线观看免费高清一 | 999久久久久久 | 日本不卡免费一区二区三区综合久久 | 青青草综合视频 | 92自拍视频 | 国产内射合集颜射 | 国产亚洲欧美日韩高清 | 无码国产精品一区二区免费16 | 毛片免费毛片一级jjj毛片 | 91精品国产综合久久久久久首页 | 亚洲无码专区三区在线观看 | 欧美日韩国产限制 | 精品一区二区中文字幕 | 永久亚洲成a人片777777 | 一本大道久久精品 | 自拍私拍网友真实视频 | 欧美一级大黄大黄大色毛片小说 | 国产又爽又猛又粗的视频A片 | 天堂色网 | 韩剧《上流社会》在线观看 | 欧美日韩国产免费一区二区三区 | 成本人在线观看视频网站 | 东京热亚洲精品中文一区 | 成人免费在线视频 | 国产一级一片免费播放 | 国产99久久亚洲综合精品西瓜tv | 男人操女人视频免费 | 久产久91精国九品打 | 激情国产AV做激情国产爱 | 女人下边被添全过程A片图片 | 污导航在线观看 | 日韩久久无码免费看A | 欧美a级v片在线观看 | 天天爽一爽 | 青青草91久久久久久久久 | 囯产精品一品二区三区 | 国产AV无码专区亚洲精品 |