97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕有码无码AV,成人三级在线观看,成年免费视频
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
DMRT1 Rabbit pAb (bs-11276R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-11276R
英文名稱 DMRT1 Rabbit pAb
中文名稱 DMRT1蛋白抗體
別    名 DM domain expressed in testis 1; DM domain expressed in testis protein 1; DMRT 1; dmrt1; DMRT1_HUMAN; DMT 1; DMT1; Doublesex and mab 3 related transcription factor 1; Doublesex- and mab-3-related transcription factor 1.  
Specific References  (1)     |     bs-11276R has been referenced in 1 publications.
[IF=2.42] Li, Taotao, et al. "Expression and cellular localization of double sex and mab-3 related transcription factor 1 in testes of postnatal Small-Tail Han sheep at different developmental stages." Gene (2017).  WB ;  Sheep.  
研究領(lǐng)域 發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human,Rat (predicted: Mouse,Sheep,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DMRT1: 51-100/373 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 DMRTA1 is a 504 amino acid protein that localizes to the nucleus and contains one DM DNA-binding domain. Expressed in prostate, liver, pancreas and kidney and present at lower levels in ovary and testis, DMRTA1 is thought to be involved in sexual developmental processes during maturation. The gene encoding DMRTA1 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Function:
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Testis-specific.

DISEASE:
Defects in DMRT1 may be a cause of testicular germ cell tumor (TGCT) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
Defects in DMRT1 may be a cause of 46,XY sex reversal type 4 (SRXY4) [MIM:54230]. A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion.

Similarity:
Belongs to the DMRT family.
Contains 1 DM DNA-binding domain.

SWISS:
Q9Y5R6

Gene ID:
1761

Database links:

Entrez Gene: 63951 Human

Entrez Gene: 242523 Mouse

Entrez Gene: 313352 Rat

Omim: 614803 Human

SwissProt: Q5VZB9 Human

SwissProt: A2AL09 Mouse

SwissProt: Q8CFG4 Mouse

Unigene: 371976 Human

Unigene: 130167 Mouse

Unigene: 43064 Rat



產(chǎn)品圖片
Tissue/cell: rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-DMRT1 Polyclonal Antibody, Unconjugated(bs-11276R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human prostate tissue;4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-DMRT1 Polyclonal Antibody, Unconjugated(bs-11276R) 1:500, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 欧美精品高清 | 伊人插插插 | 九九久久精品一区 | 久久深夜福利 | 国产成人精品日本亚洲第一区 | 国语自产拍在线视频中文 | 婷婷影院在线综合免费视频 | 国产精品久久久久久AV福利 | 亚洲精品无码一区二区三区 | 斗破苍穹年番观看免费完整观看 | 大香伊蕉最新视频 | 2024国产精品自拍 | 皇色在线视频 | 精品国产一区二区三区麻豆小说 | 韩国公妇里乱片A片 | 91视频在线观看免费 | 色久悠悠在线观看 | 精品乱码久久久久久中文字幕 | 久久久妇女国产精品影视 | 欧美日韩免费大片 | 免费A级毛片无码A∨中文字幕 | 亚洲国产精品久久亚洲精品大牛 | 久久久久久无码精品无码国产人妻丝瓜 | 亚洲欧美国产日韩精品 | 欧美成人看片 | 九九久久精品一区 | 日韩视频一区二区三区在线观看 | 亚洲好骚综合 | 国产免费观看一级国产 | 中文字幕免费精品一区高清 | 欧美男女爱爱视频 | 漂亮人妻被中出中文字幕 | 久久热这里只有精品在线观看 | 国产AV午夜精品一区二区入口 | 男人和女人做爽爽视频免费 | 亚洲福利国产精品17p | 国产美女91视频 | 18禁无遮挡免费视频网站 | 香蕉久热 | 国产三级日本三级在线播放 | 国产女人18毛片水真多1 |