97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美bbwbbwbbwxxxx,青青草在线免费,成人黄色免费网站
首頁 > 產品中心 > 一抗 > 產品信息
SRGAP1 Rabbit pAb (bs-11601R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-11601R
英文名稱 SRGAP1 Rabbit pAb
中文名稱 Rho GTP酶激活蛋白13抗體
別    名 ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN.  
研究領域 細胞生物  神經生物學  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 124 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRGAP1: 51-150/1085 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.

Function:
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Subunit:
Homodimer (Probable). Forms heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG.

Tissue Specificity:
Expressed in brain, lung, kidney, and testis.

Similarity:
Contains 1 FCH domain.
Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

SWISS:
Q7Z6B7

Gene ID:
57522

Database links:

Entrez Gene: 57522 Human

Entrez Gene: 117600 Mouse

Entrez Gene: 314903 Rat

Omim: 606523 Human

SwissProt: Q7Z6B7 Human

SwissProt: Q91Z69 Mouse

Unigene: 210751 Human

Unigene: 593803 Human

Unigene: 288698 Mouse

Unigene: 208903 Rat



產品圖片
Sample: Siha(Human) Cell Lysate at 30 ug A431(Human) Cell Lysate at 30 ug Primary: Anti- SRGAP1 (bs-11601R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 124 kD Observed band size: 124 kD
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩黄色大片在线观看 | 少妇又色又爽又高潮极品 | a在线免费看 | 涂了春药被一群人伦爽99势 | 97少妇无码视频在线播放 | 国产在线a视频 | 狠狠躁夜夜a产精品视频 | 99热6这里只有精品 国产一区=区 | av正在播放 | 中文字幕视频一区二区三区久 | 蜜桃传媒一区二区 | free性欧美1819护士 | 日本永久免费a∨在线视频 91精品国产综合久久小仙女图片 | 国产欧美一级 | 国产亚洲精品美女久久久久 | 亚洲综合图片网 | 成人精品一区二区三区免费看 | 色爱av综合网站 | 国产尺码和欧洲尺码表2022 | 亚洲AV无码AV男人的天堂不卡 | 中文字幕日韩网站免费视频 | 国产各种高潮合集在线观看 | 免费黄网站在线观看 | 欧美黑人肉体狂欢大派对 | 亚洲熟女AV综合网五月 | 久久日韩国产精品免费 | 久久大香伊蕉在人线免费 | 伊人狠狠色 | 国产日本在线视频 | 日韩精品一二区 | 久久久国产日韩 | 精品国产乱码久久久久久久 | 一级黄色在线免费观看 | 九九热精品视频在线免费观看 | 色av色av色av | 亚洲精品久久久中文字幕 | 国产真实夫妇对白视频 | 无码人妻熟妇AV又粗又大 | 亚洲人成免费网站 | 亚洲成人黄色小说 | 色欲狠狠躁天天躁无码中文字幕 |