97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
都市激情中文字幕,久久三级黄色片,欧美性大战久久久久久久蜜臀
首頁 > 產品中心 > 一抗 > 產品信息
CRBN Rabbit pAb (bs-11716R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-11716R
英文名稱 CRBN Rabbit pAb
中文名稱 cereblon蛋白抗體
別    名 Cereblon; DKFZp781K0715; MGC27358; MRT2A; OTTHUMP00000209555; piL; Protein cereblon; Protein x 0001; 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; CRBN_HUMAN.  
研究領域 細胞生物  神經生物學  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Zebrafish,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRBN: 210-288/442 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.

Function:
Protein cereblon modulates cell surface expression of KCNT1 and may be involved in memory and learning. It is highly expressed in brain and defects in CRBN are the cause of non syndromic mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP binding and catalytic domains, suggesting that it has no protease activity.

Subunit:
Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1.

Subcellular Location:
Cytoplasm. Nucleus. Membrane; Peripheral membrane protein

Tissue Specificity:
Widely expressed. Highly expressed in brain.

Post-translational modifications:
Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.

DISEASE:
Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs.

Similarity:
Belongs to the CRBN family.
Contains 1 Lon domain.

SWISS:
Q96SW2

Gene ID:
51185

Database links:

Entrez Gene: 51185 Human

Entrez Gene: 58799 Mouse

Entrez Gene: 297498 Rat

Entrez Gene: 445491 Zebrafish

GenBank: NM_016302.2 Human

Omim: 607417 Human

SwissProt: Q96SW2 Human

SwissProt: Q8C7D2 Mouse

SwissProt: Q56AP7 Rat

SwissProt: Q68EH9 Zebrafish

Unigene: 18925 Human

Unigene: 290085 Mouse

Unigene: 195259 Rat

Unigene: 84847 Zebrafish



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRBN) Polyclonal Antibody, Unconjugated (bs-11716R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CRBN Polyclonal Antibody, Unconjugated(bs-11716R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CRBN Polyclonal Antibody, Unconjugated(bs-11716R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 色播影院性播影院私人影院 | 亚洲男人的天堂在线aⅴ视频 | 女人黄色毛片 | 99久久精品免费看蜜桃的推荐词 | 精品十八禁免费观看 | 亚洲精品久久久中文字幕 | 18勿看免费大片1000拍拍 | 男女啪啪做爰高潮全过有网站 | 91国在线| 91精品国产一区二区 | 日本无遮挡色又黄的视频 | 日韩小片 | 天天色天天射天天操 | 亚洲精品尤物 | 免费一级好看的国产 | 大地资源在线观看免费高清动漫 | 国产欧美日韩精品一区二区三区 | 国产日韩1区 | 国产日韩视频在线播放 | 国产黑丝美女av | 欧美三级视频日日操 | 久久99日韩国产精品久久99 | 天天躁日日躁狠狠躁欧美老妇小说 | 人人草久久 | 蜜臀av免费一区二区三区久久乐 | 亚洲大乳av成人天堂精品 | 一区二区免费在线观看视频 | 精品无码国产AV一区二区 | 在线观看欧美一区 | 国产精品久久久久无码av | 免费人成视频在线观看播放网站 | 成人片黄色大片 | 秋霞无码一区二区视频在线观看 | 一人之下2在线观看 | 3344成人免费高清免费视频 | anquye在线观看 | 国精产品一码一码三MBA | 欧美肥妇毛多水多bbxx水蜜桃 | 国产欧美色一区二区三区 | 亚洲久久中文字幕 | 免费能直接在线观看黄的视频 |