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GPM6B Rabbit pAb (bs-11847R)  
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產品編號 bs-11847R
英文名稱 GPM6B Rabbit pAb
中文名稱 神經細胞膜糖蛋白M6b
別    名 M6b; Neuronal membrane glycoprotein M6b; rhombex 29; GPM6B_HUMAN.  
研究領域 細胞生物  發育生物學  神經生物學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Pig,Horse)
產品應用 WB=1:500-2000,Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 29 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPM6B: 1-100/265 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GPM6B belongs to the myelin proteolipid protein family and is implicated in neural development. It is expressed in neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Function:
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.

Subunit:
Interacts with SERT.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with SERT at the plasma membrane

Tissue Specificity:
Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Similarity:
Belongs to the myelin proteolipid protein family.

SWISS:
Q13491

Gene ID:
2824

Database links:

Entrez Gene: 2824 Human

Entrez Gene: 14758 Mouse

Entrez Gene: 192179 Rat

Omim: 300051 Human

SwissProt: Q13491 Human

SwissProt: P35803 Mouse

SwissProt: Q9JJK1 Rat

Unigene: 495710 Human

Unigene: 222320 Mouse

Unigene: 153513 Rat



產品圖片
Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti-GPM6B (bs-11847R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kD Observed band size: 36 kD
Sample: U251(Human) Cell Lysate at 30 ug Primary: Anti-GPM6B? (bs-11847R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kD Observed band size: 34 kD
Blank control: RSC96(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 0.2μg in 100 μL1X PBS containing 0.5% BSA(green).
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