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GPR56 Rabbit pAb (bs-11848R)  
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50ul/1180.00元
100ul/1980.00元
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產(chǎn)品編號 bs-11848R
英文名稱 GPR56 Rabbit pAb
中文名稱 蛋白偶聯(lián)受體56抗體
別    名 BFPP; DKFZp781L1398; EGF TM7 like; G protein coupled receptor 56; GPR 56; Polymicrogyria bilateral frontoparietal; TM7LN4; TM7XN1; TM7XN1 protein; GPR56_HUMAN.  
研究領域 腫瘤  細胞生物  神經(jīng)生物學  細胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 78 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR56: 275-350/693 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. G-protein coupled receptor 56 (GPR56), also designated TM7XN1 protein, contains one GPS domain. GPR56 plays an important role in cell-cell interactions and is widely expressed, with highest levels detected in brain, heart and thyroid gland. Defects in the gene encoding for GPR56 can cause bilateral frontoparietal polymicrogyria (BFPP) which is characterized by disorganized cortical lamination.

Function:
GPR56 contains 7 transmembrane domains as well as a mucin-like domain and cysteine box in the N-terminal region. Its expression is widely distributed and the highest levels can be found in brain, thyroid gland and heart. It is also expressed in a great number of tumor cells. Results show that mutations in GPR56 cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria (BFPP); data suggest that GPR56 signaling plays an essential role in regional development of human cerebral cortex.

Subcellular Location:
Cell membrane. Multi-pass membrane protein.

Tissue Specificity:
Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells.

Post-translational modifications:
The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

DISEASE:
Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP) [MIM:606854]. BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.

SWISS:
Q9Y653

Gene ID:
9289

Database links:

Entrez Gene: 9289 Human

Entrez Gene: 14766 Mouse

Entrez Gene: 260326 Rat

Omim: 604110 Human

SwissProt: Q9Y653 Human

SwissProt: Q8K209 Mouse

SwissProt: Q8K3V3 Rat

Unigene: 513633 Human

Unigene: 290834 Mouse

Unigene: 1677 Rat



產(chǎn)品圖片
Sample: K562 Cell (Human) Lysate at 40 ug Heart (Mouse) Lysate at 40 ug Primary: Anti-GPR56 (bs-11848R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78 kD Observed band size: 75 kD
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