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LPPR4 Rabbit pAb (bs-11875R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-11875R
英文名稱 LPPR4 Rabbit pAb
中文名稱 腦特異性磷脂酸磷酸酶樣蛋白1抗體
別    名 Brain-specific phosphatidic acid phosphatase-like protein 1; KIAA0455; Lipid phosphate phosphatase-related protein type 4; Lppr4; LPPR4_HUMAN; Plasticity-related gene 1 protein; PRG-1.  
研究領域 細胞生物  發育生物學  神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 83 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LPPR4: 251-360/763 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Phosphatidate phosphatases are a family of integral membrane glycoproteins that dephosphorylate a variety of lipid phosphates and play a role in signal transduction via the phospholipase D pathway. PAP-2 proteins function independently of Mg2+ and are insensitive to NEM (N-ethylmaleimide) inhibition. The lipid phosphates degraded by this family include ceramide 1-phosphate (C1P), sphingosine 1-phosphate (S1P), phosphatidic acid (PA) and lysophosphatidic acid (LPA). LPPR4 (lipid phosphate phosphatase-related protein type 4), also known as LPR4, PHP1, PRG1 or PRG-1, is a 763 amino acid multi-pass membrane protein that belongs to the PA-phosphatase related phosphoesterase family. Exclusively expressed in neurons, LPPR4 hydrolyzes lysophosphatidic acid (LPA) and facilitates axonal outgrowth during development and regenerative sprouting. LPPR4 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 1p21.2.

Function:
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

Subcellular Location:
Membrane.

Tissue Specificity:
Specifically expressed in neurons.

Similarity:
Belongs to the PA-phosphatase related phosphoesterase family.

SWISS:
Q7Z2D5

Gene ID:
9890

Database links:

Entrez Gene: 9890 Human

Omim: 607813 Human

SwissProt: Q7Z2D5 Human

Unigene: 13245 Human



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