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GPR17 Rabbit pAb (bs-12022R)  
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產品編號 bs-12022R
英文名稱 GPR17 Rabbit pAb
中文名稱 G蛋白偶聯受體17抗體
別    名 DKFZp686M18273; G protein coupled receptor 17; G-protein coupled receptor 17; GPR 17; Gpr17; GPCR17; GPR17_HUMAN; P2Y like receptor; P2Y-like receptor; Probable P2Y purinoceptor GPR 17; Probable P2Y purinoceptor GPR17; R12; UDP/CysLT receptor; Uracil nucleotide/cysteinyl leukotriene receptor.  
研究領域 神經生物學  信號轉導  細胞膜受體  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR17: 1-100/367 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.

Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q13304

Gene ID:
2840

Database links:

Entrez Gene: 2840 Human

Entrez Gene: 574402 Mouse

Entrez Gene: 767613 Rat

Omim: 603071 Human

SwissProt: Q13304 Human

SwissProt: Q6NS65 Mouse

SwissProt: Q09QM4 Rat

Unigene: 46453 Human

Unigene: 688940 Human

Unigene: 391108 Mouse

Unigene: 212749 Rat



產品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Cerebellum tissue lysates Primary: Anti-GPR17 (bs-12022R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 50 kDa
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