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NR3B Rabbit pAb (bs-12102R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-12102R
英文名稱 NR3B Rabbit pAb
中文名稱 谷氨酸受體3B抗體
別    名 Chi-1; Glutamate [NMDA] receptor subunit 3B; GRIN3B; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3B; NMD3B_HUMAN; NMDAR-L; NMDAR-L1; NMDAR3B; NR3B.  
研究領域 細胞生物  神經生物學  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 110 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NMDAR3B/NR3B: 351-395/1043 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter.

Function:
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
NR3B/GRIN3B subfamily.

SWISS:
Q8TCU5

Gene ID:
116444

Database links:

Entrez Gene: 116444 Human

Entrez Gene: 170483 Mouse

Entrez Gene: 170796 Rat

Omim: 606651 Human

SwissProt: O60391 Human

SwissProt: Q91ZU9 Mouse

SwissProt: Q8VHN2 Rat

Unigene: 660378 Human

Unigene: 391566 Mouse

Unigene: 162906 Rat




產品圖片
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NR3B) Polyclonal Antibody, Unconjugated (bs-12102R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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