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GIPC1 Rabbit pAb (bs-12304R)  
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產品編號 bs-12304R
英文名稱 GIPC1 Rabbit pAb
中文名稱 胰島素樣生長因子1受體相互作用蛋白1抗體
別    名 C19ORF3; Chromosome 19 open reading frame 3; GIPC; GLUT1 C terminal binding protein; GLUT1CBP; IGF 1 receptor interacting protein 1; IIP 1; IIP1; NIP; PDZ domain-containing protein GIPC1; Regulator of G protein signalling 19 interacting protein 1; RGS19 interacting protein 1; RGS19IP1; SEMCAP; SYNECTIIN; Tax interaction protein 2; TIP 2; GIPC1_HUMAN.  
研究領域 細胞生物  神經生物學  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Sheep,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIPC1: 101-160/333 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.

Function:
GIPC1 is a hydrophilic protein that contains 333 amino acids, including multiple phosphorylation sites and an 80 to 100 amino acid PDZ domain. PDZ domain-containing proteins typically recognize C terminal amino acids and are involved in protein network signaling. GIPC1 may be involved in G protein-linked signaling.

Subunit:
Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.

Subcellular Location:
Cell Membrane, peripheral membrane protein and Cytoplasmic.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the GIPC family.
Contains 1 PDZ (DHR) domain.

SWISS:
O14908

Gene ID:
10755

Database links:

Entrez Gene: 10755 Human

Entrez Gene: 67903 Mouse

Entrez Gene: 83823 Rat

Omim: 605072 Human

SwissProt: O14908 Human

SwissProt: Q9Z0G0 Mouse

SwissProt: Q9Z254 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GIPC1) Polyclonal Antibody, Unconjugated (bs-12304R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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