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HHIP Rabbit pAb (bs-12316R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-12316R
英文名稱 HHIP Rabbit pAb
中文名稱 HHIP蛋白抗體
別    名 FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; HIP.  
研究領域 細胞生物  發育生物學  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 77 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HHIP: 501-600/700 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling.

Function:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.

Subunit:
Interacts with all three hedgehog family members, SHH, IHH and DHH.

Subcellular Location:
Cytoplasm and Cell membrane. Secreted. The last 22 C-terminal amino acids may participate in cell membrane attachment.

Tissue Specificity:
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.

Similarity:
Belongs to the HHIP family.
Contains 2 EGF-like domains.

SWISS:
Q96QV1

Gene ID:
64399

Database links:

Entrez Gene: 540830 Cow

Entrez Gene: 64399 Human

Entrez Gene: 15245 Mouse

Omim: 606178 Human

SwissProt: Q96QV1 Human

SwissProt: Q7TN16 Mouse

Unigene: 507991 Human

Unigene: 254493 Mouse



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