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Manic Fringe Rabbit pAb (bs-12390R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-12390R
英文名稱 Manic Fringe Rabbit pAb
中文名稱 狂躁基因同源蛋白MFNG抗體
別    名 3-N-acetylglucosaminyltransferase manic fringe; beta-1; beta-1, 3-N-acetylglucosaminyltransferase manic fringe; MFNG; MFNG_HUMAN; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Sheep,Cow,Horse,Chimpanzee)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Manic Fringe/MFNG: 221-321/321 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Radical fringe plays a key role in the development of the limb bud. Lunatic fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice.

Function:
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.

Subcellular Location:
Golgi apparatus membrane.

Similarity:
Belongs to the glycosyltransferase 31 family.

SWISS:
O00587

Gene ID:
4242

Database links:

Entrez Gene: 4242 Human

Entrez Gene: 17305 Mouse

Entrez Gene: 315119 Rat

Omim: 602577 Human

SwissProt: O00587 Human

SwissProt: O09008 Mouse

Unigene: 517603 Human

Unigene: 149235 Mouse

Unigene: 102109 Rat



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