97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
911影院在线观看网站,www狠狠,亚洲国产另类久久久精品小说
首頁 > 產品中心 > 一抗 > 產品信息
phospho-PIK3 gamma (Thr1024) Rabbit pAb (bs-10278R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-10278R
英文名稱 phospho-PIK3 gamma (Thr1024) Rabbit pAb
中文名稱 磷酸化磷脂酰肌醇激酶PIK3-γ抗體
別    名 PK3CG_HUMAN; Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4, 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; 1 phosphatidylinositol 3 kinase; p120-PI3K; p120 PI3K; 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; 5-bisphosphate 3-kinase catalytic subunit gamma isoform; p110 gamma; Phosphatidylinositol 3 kinase catalytic 110 kD gamma; Phosphatidylinositol 3 kinase gamma, p110 gamma; Phosphatidylinositol 3 kinase, catalytic, gamma polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma isoform; Phosphatidylinositol-4; phosphoinositide 3 kinase catalytic gamma polypeptide; phosphoinositide 3 kinase gamma catalytic subunit; PI3-kinase subunit gamma; PI3CG; PI3K; PIK3; Pik3cg; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG.  
Specific References  (1)     |     bs-10278R has been referenced in 1 publications.
[IF=1.516] Lv Qing. et al. Allicin suppresses growth and metastasis of gastric carcinoma: the key role of microRNA-383-5p-mediated inhibition of ERBB4 signaling. Biosci Biotech Bioch. 2020 Oct;84(10):1997-2004  WB ;  Human.  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉導  激酶和磷酸酶  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 121 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PIK3 gamma around the phosphorylation site of Thr1024: HH(p-T)NL 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008].

Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Subunit:
Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with ADRBK1 through the PIK helical domain. Interaction with ADRBK1 is required for targeting to agonist-occupied receptor. Interacts with PDE3B. Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS1; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).

Subcellular Location:
Cytoplasm. Cell membrane.

Tissue Specificity:
Pancreas, skeletal muscle, liver and heart.

Similarity:
Belongs to the PI3/PI4-kinase family.
Contains 1 C2 PI3K-type domain.
Contains 1 PI3K-ABD domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

SWISS:
P48736

Gene ID:
5294

Database links:

Entrez Gene: 5294 Human

GenBank: AF327656 Human

Omim: 601232 Human

SwissProt: P48736 Human

Unigene: 32942 Human



產品圖片
Sample: Jurkat(Human) Cell Lysate at 30 ug NIH/3T3(Mouse) Cell Lysate at 30 ug HL60(Human) Cell Lysate at 30 ug Primary: Anti- phospho-PIK3 gamma (Thr1024) (bs-10278R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kD Observed band size: 121 kD
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久久久久久久免费 | 国产精品国产三级国AV | 水蜜桃AV无码 | 国产精品高潮呻吟av久久动 | 精品人妻无码一区二区三区丝袜 | 久久不见久久见中文字幕免费 | 级R片内射在线视频播放 | 久久精品人妻无码一区二区三区 | 日本a人精品 | 中出乱码av亚洲精品久久天堂 | 日韩精品久久久久久久软件91 | 最新大地资源网在线观看免费 | aaa大片在线观看 | 无人高清视频免费观看在线 | 色综合久久精品 | 超碰91资源 | 国产日本在线视频 | 欧美专区日韩 | 久久久久久无码精品无码国产人妻丝瓜 | 国产日韩视频在线播放 | 强插女教师AV在线 | 在线观看视频网站www色 | 国产视频不卡一区 | 乱亲女h秽乱长久久久 | 国产精品特级片 | 人妻一本久道久久综合久久鬼色 | 草逼一级片 | 好久不见在线观看免费高清 | 国外精品久久久蜜桃免费全文阅读 | 色噜噜亚洲男人的天堂 | 唐人街探案网剧免费观看 | 夜夜爱天天干 | 免费人成视频在线观看播放网站 | 97人伦影院A级毛片 操操网址 | 国产精品久久久久无码 | 九一天堂| 无码AV无码一区二区桃花岛 | 国内精品国产三级国产 | 欧美一级久久久猛烈a大片 国产吹潮视频在线观看 | 色婷婷五月综合丁香中文字幕 | 精品国产乱码一区二区三区99 |