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DOPEY1 Rabbit pAb (bs-14409R)  
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產品編號 bs-14409R
英文名稱 DOPEY1 Rabbit pAb
中文名稱 遲鈍蛋白家族1抗體
別    名 Dopey-1; DOP1; DOP1_HUMAN; Dopey family member 1; DOPEY1; KIAA1117; Protein dopey 1; Protein dopey-1.  
研究領域 神經生物學  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 277 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DOPEY1: 351-450/2465 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Dopey-1 is a 2,465 amino acid protein that is thought to be involved in protein trafficking between the late golgi and early endosomes and may be involved in neurological alternations and mental retardation associated with Down syndrome. The gene encoding Dopey-1 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Function:
May be involved in protein traffic between late Golgi and early endosomes.

Similarity:
Belongs to the dopey family.

SWISS:
Q5JWR5

Gene ID:
23033

Database links:

Entrez Gene: 23033 Human

Entrez Gene: 320615 Mouse

SwissProt: Q5JWR5 Human

SwissProt: Q8BL99 Mouse

Unigene: 520246 Human

Unigene: 708998 Human

Unigene: 245500 Mouse



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DOPEY1) Polyclonal Antibody, Unconjugated (bs-14409R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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