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DTX3 Rabbit pAb (bs-14437R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-14437R
英文名稱(chēng) DTX3 Rabbit pAb
中文名稱(chēng) DTX3蛋白抗體
別    名 Deltex3; Dtx3; DTX3_HUMAN; Protein deltex 3; Protein deltex-3; RING finger protein 154; RNF154.  
研究領(lǐng)域 細(xì)胞生物  干細(xì)胞  表觀(guān)遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 38 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DTX3: 1-100/347 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Subunit:
Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By similarity).

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the Deltex family.
Contains 1 RING-type zinc finger.

SWISS:
Q8N9I9

Gene ID:
196403

Database links:

Entrez Gene: 196403 Human

Entrez Gene: 80904 Mouse

Omim: 613142 Human

SwissProt: Q8N9I9 Human

SwissProt: Q80V91 Mouse

Unigene: 32374 Human

Unigene: 271724 Mouse



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