97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
伊人色综合久久久天天蜜桃,性色av一区二区三区免费播放 ,gogogo免费观看
首頁 > 產品中心 > 一抗 > 產品信息
Kindlin Rabbit pAb (bs-17063R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-17063R
英文名稱 Kindlin Rabbit pAb
中文名稱 整合素相互作用蛋白Kindlin抗體
別    名 C20orf42; Chromosome 20 open reading frame 42; DTGCU 2; DTGCU2; FERM1_HUMAN; Fermitin family homolog 1; Fermt1; FLJ20116; FLJ23423; KIND 1; KIND1; Kinderlin; Kindlerin; Kindlin 1; Kindlin syndrome protein; Kindlin-1; Kindlin1; Unc 112 related protein 1; Unc-112-related protein 1; Unc112 related protein; UNC112A; URP 1; URP1.  
研究領域 腫瘤  細胞生物  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 77 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Kindlin: 601-677/677 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]

Function:
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Cell projection > ruffle membrane. Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.

Tissue Specificity:
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.

DISEASE:
Defects in FERMT1 are the cause of Kindler syndrome (KINDS) [MIM:173650]. An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Note=Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020).

Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.

SWISS:
Q9BQL6

Gene ID:
55612

Database links:

Entrez Gene: 55612 Human

Entrez Gene: 524427 Cow

Entrez Gene: 241639 Mouse

Omim: 607900 Human

SwissProt: Q9BQL6 Human

SwissProt: P59113 Mouse

Unigene: 472054 Human

Unigene: 209784 Mouse



Kindlin家族是新近發現的粘著斑蛋白(focal adhesion protein),有3個成員(Kindlin-1、Kindlin-2、Kindlin-3)。Kindlin家族參與整合素活化、細胞遷移、增殖和分化的調控,在臨床上與皮膚疾病發生、腫瘤的侵襲、心血管生成、免疫系統功能有密切關系。Kindlins異常可以導致多種遺傳性疾病,如Kindlin-1功能異常導致Kindler綜合征(Kindler syndrome,KS)和Kindlin-3功能異常導致白細胞黏附缺陷(1eukocyte adhesion deficiency,LAD—HI)。目前已在人類實體腫瘤(乳腺癌、前列腺癌、平滑肌肉瘤)中發現Kindlin-2與腫瘤的侵襲性及耐藥性有關。
產品圖片
Paraformaldehyde-fixed, paraffin embedded (human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kindlin) Polyclonal Antibody, Unconjugated (bs-17063R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kindlin) Polyclonal Antibody, Unconjugated (bs-17063R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: japanese国产乱在线播放 | eeuss影院www免费播放 | 国产猛男猛女无遮无掩 | 久久久久亚洲一区二区三区 | 欧美激情一区在线 | 亚洲第一男人天堂 | 亚洲AV永久无码天堂网国产 | 亚洲欧美天堂在线 | 人妻少妇看A偷人无码精品 在教室伦流澡到高潮h麻豆 | 免费精品国产福利片 | 欧美成人精品a片免费区网站 | 亚洲国产成人久久综合人 | 色av色av色av| 欧美最厉害的喷水VIDEOS | 久草网首页 | 青涩av | 狠狠色丁香六月色 | 亚洲成人高清av | 黄网站在线观 | 色综合伊人丁香五月桃花婷婷 | 亚洲美女视频 | 国产稚嫩高中生呻吟激情在线视频 | 日本在线播放一二三区 | 国产精品欧美一区二区 | 丁香五月色情婷婷在线观看 | 788好吊妞视频gaocom | 欧美一区二区三区 | 国产在线视精品在一区二区 | 久久天天躁狠狠躁夜夜96流白浆 | 日本精品在线播放 | 天天色综 | 黄色毛片大全 | 一区二区三区免费看视频 | 免费精品久久久久久久一区二区 | 一级做a爰片性色毛片是免费 | 人人爱97| 99热婷婷| 99久久久久免费精品国产 | 国产精品欧美综合亚洲 | 精一区二区三区 | 亚洲欧美第一成人网站7777 |