97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
伊人色综合久久久天天蜜桃,性色av一区二区三区免费播放 ,gogogo免费观看
首頁 > 產品中心 > 一抗 > 產品信息
Kindlin Rabbit pAb (bs-17063R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-17063R
英文名稱 Kindlin Rabbit pAb
中文名稱 整合素相互作用蛋白Kindlin抗體
別    名 C20orf42; Chromosome 20 open reading frame 42; DTGCU 2; DTGCU2; FERM1_HUMAN; Fermitin family homolog 1; Fermt1; FLJ20116; FLJ23423; KIND 1; KIND1; Kinderlin; Kindlerin; Kindlin 1; Kindlin syndrome protein; Kindlin-1; Kindlin1; Unc 112 related protein 1; Unc-112-related protein 1; Unc112 related protein; UNC112A; URP 1; URP1.  
研究領域 腫瘤  細胞生物  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 77 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Kindlin: 601-677/677 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]

Function:
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Cell projection > ruffle membrane. Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.

Tissue Specificity:
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.

DISEASE:
Defects in FERMT1 are the cause of Kindler syndrome (KINDS) [MIM:173650]. An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Note=Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020).

Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.

SWISS:
Q9BQL6

Gene ID:
55612

Database links:

Entrez Gene: 55612 Human

Entrez Gene: 524427 Cow

Entrez Gene: 241639 Mouse

Omim: 607900 Human

SwissProt: Q9BQL6 Human

SwissProt: P59113 Mouse

Unigene: 472054 Human

Unigene: 209784 Mouse



Kindlin家族是新近發現的粘著斑蛋白(focal adhesion protein),有3個成員(Kindlin-1、Kindlin-2、Kindlin-3)。Kindlin家族參與整合素活化、細胞遷移、增殖和分化的調控,在臨床上與皮膚疾病發生、腫瘤的侵襲、心血管生成、免疫系統功能有密切關系。Kindlins異常可以導致多種遺傳性疾病,如Kindlin-1功能異常導致Kindler綜合征(Kindler syndrome,KS)和Kindlin-3功能異常導致白細胞黏附缺陷(1eukocyte adhesion deficiency,LAD—HI)。目前已在人類實體腫瘤(乳腺癌、前列腺癌、平滑肌肉瘤)中發現Kindlin-2與腫瘤的侵襲性及耐藥性有關。
產品圖片
Paraformaldehyde-fixed, paraffin embedded (human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kindlin) Polyclonal Antibody, Unconjugated (bs-17063R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kindlin) Polyclonal Antibody, Unconjugated (bs-17063R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产第3页| 亚洲欧美视频播放 | 性做久久 | 夜夜操天天射 | 国产暴力强伦轩1区二区小说 | 亚洲av无码免费成人av | 久久精品国产99精品最新 | 亚洲精品视频在线观看网站 | 国产在线观看第一页 | 国产女教师一爽a片 | 久久婷婷五月综合色丁香 | 免费看片国产 | 澳门久久久 | 狠狠色狠狠色综合久久 | LULUHEI噜噜黑最新地址 | 精品久久久久久 | 亚洲午夜精品一区二区三区 | 受被攻c哭高h视频在线观看 | 国产日韩中文字幕在线 | 久久艹逼 | av网站免费在线播放 | 国产成人在线高清 | 国产精成人品日日拍夜夜免费 | 国产欧美久久一区二区三区 | 三个男人躁我一个爽公交车上 | 年轻内射无码视频 | 中国亚州女人69内射少妇 | 性生大片免费观看网站蜜芽 | 亚洲AV无码一区二区三区观看 | 伊人狠狠色j香婷婷综合 | 无码免费一区二区三区免费播放 | 欧美亚洲精品一区二区在线观看 | 性欧美另类黑人巨大HD | 国内毛片毛片毛片毛片毛片毛片 | 免费吃奶摸下激烈视频青青网 | 国产精品无码免费视频二三区 | 69中文字幕 | 一级毛片免费播放 | 亚洲精品一区二区制服 | 成人午夜片av在线看 | 久久久妇女国产精品影视 |