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Josephin-2 Rabbit pAb (bs-17207R)  
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產(chǎn)品編號 bs-17207R
英文名稱 Josephin-2 Rabbit pAb
中文名稱 JOSD2蛋白抗體
別    名 FLJ29018; JOS2_HUMAN; JOSD 2; JOSD2; Josephin 2; Josephin domain containing 2; Josephin domain containing protein 2; Josephin domain-containing protein 2; Josephin-2; Josephin2; SBBI54.  
研究領域 細胞生物  免疫學  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse)
產(chǎn)品應用 WB=1:500-2000,Flow-Cyt=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Josephin-2: 91-188/188 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Josephin-2, also known as JOSD2 (josephin domain containing 2), is a 188 amino acid protein that contains one josephin domain and is encoded by a gene that maps to human chromosome 19. Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.

Function:
Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

Similarity:
Contains 1 Josephin domain.

SWISS:
Q8TAC2

Gene ID:
126119

Database links:

Entrez Gene: 611845 Dog

Entrez Gene: 126119 Human

Entrez Gene: 66124 Mouse

Entrez Gene: 292876 Rat

SwissProt: Q8TAC2 Human

SwissProt: Q9CR30 Mouse

Unigene: 467151 Human

Unigene: 358691 Mouse

Unigene: 22861 Rat



產(chǎn)品圖片
Sample: Lane 1: Human MCF-7 cell lysates Lane 2: Human U251 cell lysates Lane 3: Human HT-1080 cell lysates Lane 4: Human A431 cell lysates Primary: Anti-Josephin-2 (bs-17207R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 21 kDa Observed band size: 15,21 kDa
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