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FGL2 Rabbit pAb (bs-10587R)  
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50ul/1180.00元
100ul/1980.00元
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產品編號 bs-10587R
英文名稱 FGL2 Rabbit pAb
中文名稱 凝血酶原酶/維介素抗體
別    名 Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN.  
研究領域 免疫學  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Rat (predicted: Mouse,Rabbit,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 49 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGL2: 231-330/439 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1.

Function:
May play a role in physiologic lymphocyte functions at mucosal sites

Subunit:
Homotetramer; disulfide-linked.

Subcellular Location:
Secreted.

Tissue Specificity:
Constitutively expressed in cytotoxic T-cells.

Similarity:
Contains 1 fibrinogen C-terminal domain.

SWISS:
Q14314

Gene ID:
10875

Database links:

Entrez Gene: 511711 Cow

Entrez Gene: 10875 Human

Entrez Gene: 14190 Mouse

Entrez Gene: 84586 Rat

Omim: 605351 Human

SwissProt: Q14314 Human

SwissProt: P12804 Mouse

Unigene: 520989 Human

Unigene: 292100 Mouse



產品圖片
Sample: Raji(Human) Cell Lysate at 40 ug Primary: Anti-FGL2 (bs-10587R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kD Observed band size: 49 kD
Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FGL2) Polyclonal Antibody, Unconjugated (bs-10587R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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