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SIRPB2 Rabbit pAb (bs-17499R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-17499R
英文名稱 SIRPB2 Rabbit pAb
中文名稱 信號(hào)調(diào)節(jié)蛋白β2/SIRP-β2抗體
別    名 BIG 3; dJ776F14.2; Protein tyrosine phosphatase non-receptor type substrate 1-like 3; Protein tyrosine phosphatase non-receptor type substrate protein; PTPNS1L3; RP4-776F14.1; Signal-regulatory protein beta-2; SIRB2_HUMAN; SIRP-beta-2; SIRPB2.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIRPB2: 31-130/342 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SIRPs are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-kinase pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-alpha 1 is a transmembrane protein which acts as a substrate for activated receptor tyrosine kinases and, in its tyrosine phosphorylated form, binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha 1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and Insulin. SIRP-beta 1 shares extensive sequence homology with SIRP-alpha 1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-beta 2 is a 342 amino acid multi-pass membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains and exists as multiple alternatively spliced isoforms.

Subcellular Location:
Membrane.

Similarity:
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

SWISS:
Q5JXA9

Gene ID:
284759

Database links:

Entrez Gene: 284759 Human

SwissProt: Q5JXA9 Human

Unigene: 721685 Human



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