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MST1/MST2 Rabbit pAb (bs-8477R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-8477R
英文名稱 MST1/MST2 Rabbit pAb
中文名稱 蛋白激酶MST1/2抗體
別    名 DKFZp686A2068; FLJ90748; KRS1; KRS2; Mammalian STE20 like protein kinase 1; Mammalian STE20 like protein kinase 2; MST 1; MST 2; MST1; MST2; Serine/threonine kinase 3(STE20 homolog yeast); Serine/threonine kinase 3(Ste20 yeast homolog); Serine/threonine kinase 3; Serine/threonine kinase 4; Serine/threonine protein kinase 3; Serine/threonine protein kinase 4; Serine/threonine protein kinase Krs 1; Serine/threonine protein kinase Krs 2; STE20 like kinase MST1; STE20 like kinase MST2; STK 3; STK 4; STK3; STK4; YSK3.  
Specific References  (1)     |     bs-8477R has been referenced in 1 publications.
[IF=5.589] Gao R et al. PM2.5-associated?nitro-PAH?exposure?promotes?tumor?cell?metastasis?through?Hippo-YAPmediated?transcriptional?regulation. Sci Total Environ. 2019 Aug 15;678:611-617.  WB ;  Human.  
研究領(lǐng)域 細胞生物  免疫學  信號轉(zhuǎn)導  細胞凋亡  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:50
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MST1/MST2 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function:
The human serine/threonine kinase, mammalian STE20 like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor mediated apoptosis by accelerating caspase 3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation. MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. Mammalian Sterile 20 Like 2 (MST2) is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in vitro kinase assay indicates that MST2 can phosphorylate an exogenous substrate, as well as itself, and phospho amino acid analysis indicates that it is a serine/threonine protein kinase.

Subcellular Location:
Cytoplasm. Nucleus. Note: The caspase cleaved form cycles between the nucleus and cytoplasm.

SWISS:
Q13188

Gene ID:
6789

Database links:

Entrez Gene: 6788 Human

Entrez Gene: 6789 Human

Entrez Gene: 311622 Rat

Entrez Gene: 65189 Rat

Omim: 604965 Human

Omim: 605030 Human

SwissProt: Q13043 Human

SwissProt: Q13188 Human

SwissProt: O54748 Rat



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