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HDAC4 + 5 + 9 Rabbit pAb (bs-10763R)  
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50ul/1180.00元
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產品編號 bs-10763R
英文名稱 HDAC4 + 5 + 9 Rabbit pAb
中文名稱 組蛋白去乙酰化酶4+5+9抗體
別    名 AHO3; Antigen NY-CO-9; BDMR; HA6116; HD4; HD5; HD7; HD7b; HD9; HDAC; HDAC-4; HDACA; HDAC4; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDRP; Histone deacetylase 4; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; MITR; NY-CO-9; HDAC4_HUMAN; HDAC5_HUMAN; HDAC9_HUMAN.  
研究領域 細胞生物  神經生物學  信號轉導  干細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 119/122/111 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9: 651-750/1084 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. HDAC5: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. HDAC9: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gi es a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and de elopmental e ents. Histone deacetylases act ia the formation of large multiprotein complexes. In ol ed in muscle maturation ia its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Subunit:
Interacts with HDAC7. Homodimer. Homodimerization ia its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B. Interacts with KDM5B. Interacts with MYOCD. Interacts with MORC2. Interacts with ANKRA2.

Subcellular Location:
HDAC4: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. HDAC5: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. HDAC9: Nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.
Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and pre ented by phosphorylation by CaMK4.

DISEASE:
Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, de elopmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.

SWISS:
P56524

Gene ID:
9759

Database links:

Entrez Gene: 10014 Human

Entrez Gene: 9734 Human

Entrez Gene: 9759 Human

Entrez Gene: 15184 Mouse

Entrez Gene: 208727 Mouse

Entrez Gene: 79221 Mouse

Entrez Gene: 314040 Rat

Entrez Gene: 363287 Rat

Entrez Gene: 84580 Rat

Omim: 605314 Human

Omim: 605315 Human

Omim: 606543 Human

SwissProt: P56524 Human

SwissProt: Q9UKV0 Human

SwissProt: Q9UQL6 Human

SwissProt: Q6NZM9 Mouse

SwissProt: Q99N13 Mouse

SwissProt: Q9Z2V6 Mouse

SwissProt: Q99P99 Rat



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